Linked Life Data

12934668

Source:http://linkedlifedata.com/resource/pubmed/id/12934668

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2003-8-25
pubmed:abstractText
Both tumor necrosis factor-alpha (TNF-alpha) and EFA deficiency (EFAD) have been established as causes of marked perturbations in lipid and lipoprotein metabolism. Excessive levels of circulating TNF-alpha can coexist with EFAD in various clinical disorders such as cystic fibrosis and type I diabetes. The present study therefore aimed to investigate their combined effects on lipid profile and lipoprotein composition by administering TNF-alpha to EFAD rats. Lipoprotein lipase (LPL), the rate-limiting enzyme in TG catabolism, was also measured in epididymal adipose tissue. EFAD, after a 4-wk period, induced significant increases in plasma TG (80%, P < 0.001), total cholesterol (TC, 27%, P < 0.025), and HDL-cholesterol (HDL-C, 62%). Two hours after the administration of TNF-alpha, a further rise in TG (43%, P < 0.05) was noted in controls, but not EFAD animals. TC and HDL-C were unaffected by TNF-alpha treatment. In addition, TNF-alpha modified lipoprotein-lipid composition. VLDL and HDL2 derived from EFAD rats were depleted in apolipoprotein (apo) E and apo A-II, and enriched in apo A-I 2 h after TNF-alpha administration. Finally, TNF-alpha decreased adipose tissue LPL activity in both control and EFAD animals. The TNF-alpha-induced inhibition was more marked in EFAD rats. The present results demonstrated that TNF-alpha can amplify or antagonize the effects of EFAD on lipid profile, lipoprotein composition, and LPL activity. These data also suggest that the host's nutritional status is a determining factor for the modulating effect of TNF-alpha on lipid metabolism.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0024-4201
pubmed:author
pubmed:issnType
Print
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
595-602
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Combined effects of EFA deficiency and tumor necrosis factor-alpha on circulating lipoproteins in rats.
pubmed:affiliation
Department of Nutrition, Centre de Recherche, Hôpital Ste-Justine, Université de Montréal, Montréal, Québec, Canada, H3T 1C5. levye@justine.umontreal.ca
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't