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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2003-8-8
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pubmed:abstractText |
Tumor necrosis factor-alpha (TNF-alpha) is a well-documented central inflammatory mediator in sepsis. Specific polymorphisms of the TNF-alpha and TNF-beta genes (TNF2 and LTA + 250, respectively) have been suggested to correlate with higher mortality in septic shock. This study sought to determine whether these polymorphisms of the TNF-alpha and -beta genes are associated with an increased risk of infection in an at-risk surgical intensive care population.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1096-2964
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
163-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12906716-Aged,
pubmed-meshheading:12906716-Base Sequence,
pubmed-meshheading:12906716-Critical Illness,
pubmed-meshheading:12906716-Cross Infection,
pubmed-meshheading:12906716-Female,
pubmed-meshheading:12906716-Genetic Predisposition to Disease,
pubmed-meshheading:12906716-Humans,
pubmed-meshheading:12906716-Intensive Care,
pubmed-meshheading:12906716-Lymphotoxin-alpha,
pubmed-meshheading:12906716-Male,
pubmed-meshheading:12906716-Middle Aged,
pubmed-meshheading:12906716-Polymorphism, Genetic,
pubmed-meshheading:12906716-Risk,
pubmed-meshheading:12906716-Sepsis,
pubmed-meshheading:12906716-Shock, Septic,
pubmed-meshheading:12906716-Systemic Inflammatory Response Syndrome,
pubmed-meshheading:12906716-Treatment Outcome,
pubmed-meshheading:12906716-Tumor Necrosis Factor-alpha
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pubmed:year |
2003
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pubmed:articleTitle |
Influence of the TNF-alpha and TNF-beta polymorphisms upon infectious risk and outcome in surgical intensive care patients.
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pubmed:affiliation |
Department of Surgery, UMDNJ-Robert Wood Johnson Medical School, New Brunswick 08903, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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