Linked Life Data

12900541

Source:http://linkedlifedata.com/resource/pubmed/id/12900541

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-4
pubmed:dateCreated
2003-8-5
pubmed:abstractText
Mutations in the DNMT3B DNA methyltransferase gene cause the ICF immunodeficiency syndrome. The targets of this DNA methyltransferase are CpG-rich heterochromatic regions, including pericentromeric satellites and the inactive X chromosome. The abnormal hypomethylation in ICF cells provides an important model system for determining the relationships between replication time, CpG island methylation, chromatin structure, and gene silencing in X chromosome inactivation.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1424-859X
pubmed:author
pubmed:copyrightInfo
Copyright 2002 S. Karger AG, Basel
pubmed:issnType
Electronic
pubmed:volume
99
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
25-9
pubmed:dateRevised
2010-5-21
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
ICF syndrome cells as a model system for studying X chromosome inactivation.
pubmed:affiliation
Department of Medicine, University of Washington, Seattle WA 98195-7720, USA. gartler@genetics.washington.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review