12897019

Source:http://linkedlifedata.com/resource/pubmed/id/12897019

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0014597, umls-concept:C0015272, umls-concept:C0033684, umls-concept:C0033819, umls-concept:C0120465, umls-concept:C0332307, umls-concept:C0441655, umls-concept:C0521009, umls-concept:C1269955, umls-concept:C1327616, umls-concept:C2699153
pubmed:issue	16
pubmed:dateCreated	2003-8-4
pubmed:abstractText	We report the characterization of BopE, a type III secreted protein that is encoded adjacent to the Burkholderia pseudomallei bsa locus and is homologous to Salmonella enterica SopE/SopE2. Inactivation of bopE impaired bacterial entry into HeLa cells, indicating that BopE facilitates invasion. Consistent with this notion, BopE expressed in eukaryotic cells induced rearrangements in the subcortical actin cytoskeleton, and purified BopE exhibited guanine nucleotide exchange factor activity for Cdc42 and Rac1 in vitro.
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/2985120R
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Actins, http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Guanine Nucleotide Exchange Factors, http://linkedlifedata.com/resource/pubmed/chemical/SopE protein, Salmonella, http://linkedlifedata.com/resource/pubmed/chemical/cdc42 GTP-Binding Protein, http://linkedlifedata.com/resource/pubmed/chemical/rac1 GTP-Binding Protein
pubmed:status	MEDLINE
pubmed:month	Aug
pubmed:issn	0021-9193
pubmed:author	pubmed-author:BrownPhilip JPJ, pubmed-author:FriebelAndreaA, pubmed-author:GalyovEdouard EEE, pubmed-author:HardtWolf-DietrichWD, pubmed-author:StevensMark PMP, pubmed-author:TaylorLowrie ALA, pubmed-author:WoodMichael WMW
pubmed:issnType	Print
pubmed:volume	185
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	4992-6
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:12897019-Actins, pubmed-meshheading:12897019-Bacterial Proteins, pubmed-meshheading:12897019-Burkholderia pseudomallei, pubmed-meshheading:12897019-Guanine Nucleotide Exchange Factors, pubmed-meshheading:12897019-HeLa Cells, pubmed-meshheading:12897019-Humans, pubmed-meshheading:12897019-Virulence, pubmed-meshheading:12897019-cdc42 GTP-Binding Protein, pubmed-meshheading:12897019-rac1 GTP-Binding Protein
pubmed:year	2003
pubmed:articleTitle	A Burkholderia pseudomallei type III secreted protein, BopE, facilitates bacterial invasion of epithelial cells and exhibits guanine nucleotide exchange factor activity.
pubmed:affiliation	Division of Environmental Microbiology, Institute for Animal Health, Compton Laboratory, Berkshire RG20 7NN, United Kingdom.
pubmed:publicationType	Journal Article