Source:http://linkedlifedata.com/resource/pubmed/id/12873792
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
2003-7-22
|
pubmed:abstractText |
Immunohistochemical analysis of the male and female rat adenohypophysis revealed that chromogranin A (CgA), beta-granin and WE-14 immunostaining was localised to follicle stimulating hormone (FSH) producing cells, while luteinizing hormone (LH) producing cells exhibited chromogranin A and beta-granin immunostaining. The intensity of chromogranin A, beta-granin and WE-14 immunostaining exhibited variation during the oestrous cycle; weak immunostaining was observed during proestrous and oestrous, corresponding with the lowest cellular concentration of luteinizing and follicle stimulating hormone. Chromogranin A and beta-granin immunostaining were similar in both the male and female (at dioestrous), however, a larger number of more intense WE-14 immunopositive cells were evident in the male adenohypophysis relative to the female at any stage of the cycle. The tissue and plasma concentrations of beta-granin and WE-14 immunoreactivity fluctuated throughout the oestrous cycle. Maximum and minimum beta-granin and WE-14 tissue concentration counterpoised the latent maximum and minimum plasma concentration. Chromatographic analysis of adenohypophysis extracts revealed the degree of chromogranin A proteolysis throughout the oestrous cycle; in contrast, plasma profiles consistently possessed a large chromogranin A-like immunoreactant. This data suggests that chromogranin A biosynthesis, proteolysis and the secretion of its derived peptides parallels that of the gonadotroph hormones throughout the oestrous cycle.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Chromogranin A,
http://linkedlifedata.com/resource/pubmed/chemical/Chromogranins,
http://linkedlifedata.com/resource/pubmed/chemical/Follicle Stimulating Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Luteinizing Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/beta-granins,
http://linkedlifedata.com/resource/pubmed/chemical/chromogranin A, rat,
http://linkedlifedata.com/resource/pubmed/chemical/chromogranin A-derived peptide...
|
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
|
pubmed:issn |
0167-0115
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
15
|
pubmed:volume |
115
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1-10
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:12873792-Animals,
pubmed-meshheading:12873792-Chromatography,
pubmed-meshheading:12873792-Chromogranin A,
pubmed-meshheading:12873792-Chromogranins,
pubmed-meshheading:12873792-Estrous Cycle,
pubmed-meshheading:12873792-Female,
pubmed-meshheading:12873792-Follicle Stimulating Hormone,
pubmed-meshheading:12873792-Immunohistochemistry,
pubmed-meshheading:12873792-Luteinizing Hormone,
pubmed-meshheading:12873792-Male,
pubmed-meshheading:12873792-Neoplasm Proteins,
pubmed-meshheading:12873792-Pituitary Gland, Anterior,
pubmed-meshheading:12873792-Protein Processing, Post-Translational,
pubmed-meshheading:12873792-Radioimmunoassay,
pubmed-meshheading:12873792-Rats,
pubmed-meshheading:12873792-Rats, Wistar
|
pubmed:year |
2003
|
pubmed:articleTitle |
Chromogranin A proteolysis to generate beta-granin and WE-14 in the adenohypophysis during the rat oestrous cycle.
|
pubmed:affiliation |
School of Medicine, Obstetrics and Gynaecology, Queen's University of Belfast, Institute of Clinical Science, Grosvenor Road, Belfast, BT12 6BJ, Northern Ireland, UK. c.mcvicar@qub.ac.uk
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|