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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2003-7-9
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pubmed:abstractText |
PTP1B has been shown to be a negative regulator of the insulin signal transduction in insulin resistant states. Herein we investigated IR/PTP1B interaction and downstream signaling in insulin sensitive tissues of 10 and 28-week-old MSG-insulin resistant rats which represent different stages of insulin resistance. Our results demonstrated that the increase in PTP1B expression and/or association with IR in MSG animals may contribute to the impaired insulin signaling mainly in liver and muscle. Although, adipose tissue of 10-week-old MSG rats showed higher PTP1B expression and IR/PTP1B interaction, they were not sufficient to impair all insulin signaling since IRS-2 phosphorylation and association with PI3-kinase and Akt serine phosphorylation were increased, which may contribute for the increased adiposity of these animals. In 28-week-old-MSG rats there was an increase in IR/PTP1B interaction and reduced insulin signaling in liver, muscle and adipocytes, and a more pronounced insulin resistance.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Akt1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin Receptor Substrate Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Irs1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Irs2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatase...,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/Ptpn1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium Glutamate,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0024-3205
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
73
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1369-81
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:12850498-Adipose Tissue,
pubmed-meshheading:12850498-Aging,
pubmed-meshheading:12850498-Animals,
pubmed-meshheading:12850498-Animals, Newborn,
pubmed-meshheading:12850498-Insulin,
pubmed-meshheading:12850498-Insulin Receptor Substrate Proteins,
pubmed-meshheading:12850498-Insulin Resistance,
pubmed-meshheading:12850498-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:12850498-Liver,
pubmed-meshheading:12850498-Male,
pubmed-meshheading:12850498-Muscle, Skeletal,
pubmed-meshheading:12850498-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:12850498-Phosphoproteins,
pubmed-meshheading:12850498-Phosphorylation,
pubmed-meshheading:12850498-Protein Tyrosine Phosphatase, Non-Receptor Type 1,
pubmed-meshheading:12850498-Protein Tyrosine Phosphatases,
pubmed-meshheading:12850498-Protein-Serine-Threonine Kinases,
pubmed-meshheading:12850498-Proto-Oncogene Proteins,
pubmed-meshheading:12850498-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:12850498-Rats,
pubmed-meshheading:12850498-Rats, Wistar,
pubmed-meshheading:12850498-Receptor, Insulin,
pubmed-meshheading:12850498-Signal Transduction,
pubmed-meshheading:12850498-Sodium Glutamate,
pubmed-meshheading:12850498-Tyrosine
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pubmed:year |
2003
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pubmed:articleTitle |
Modulation of IR/PTP1B interaction and downstream signaling in insulin sensitive tissues of MSG-rats.
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pubmed:affiliation |
Departamento de Clínica Médica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, FCM-UNICAMP, 13081-970 Campinas, SP, Brazil.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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