Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2003-7-1
pubmed:abstractText
The purine nucleoside adenosine acts via four distinct adenosine receptor subtypes: the adenosine A(1), A(2A), A(2B), and A(3) receptor. They are all G protein-coupled receptors (GPCR) coupling to classical second messenger pathways such as modulation of cAMP production or the phospholipase C (PLC) pathway. In addition, they couple to mitogen-activated protein kinases (MAPK), which could give them a role in cell growth, survival, death and differentiation. Although each of the adenosine receptors can activate one or more of the MAPKs, the mechanisms appear to differ substantially, both between receptor subtypes in the same cell type and between the same receptor in different cell types.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine, http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP, http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein..., http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 1, http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 3, http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Adenosine A1, http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Adenosine A2A, http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Adenosine A2B, http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Adenosine A3, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adenosine A2, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Purinergic P1, http://linkedlifedata.com/resource/pubmed/chemical/Type C Phospholipases, http://linkedlifedata.com/resource/pubmed/chemical/p38 Mitogen-Activated Protein...
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0898-6568
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
813-27
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:12834807-Adenosine, pubmed-meshheading:12834807-Animals, pubmed-meshheading:12834807-Cyclic AMP, pubmed-meshheading:12834807-Endocytosis, pubmed-meshheading:12834807-GTP-Binding Proteins, pubmed-meshheading:12834807-Humans, pubmed-meshheading:12834807-JNK Mitogen-Activated Protein Kinases, pubmed-meshheading:12834807-Mitogen-Activated Protein Kinase 1, pubmed-meshheading:12834807-Mitogen-Activated Protein Kinase 3, pubmed-meshheading:12834807-Mitogen-Activated Protein Kinases, pubmed-meshheading:12834807-Models, Biological, pubmed-meshheading:12834807-Phosphorylation, pubmed-meshheading:12834807-Receptor, Adenosine A1, pubmed-meshheading:12834807-Receptor, Adenosine A2A, pubmed-meshheading:12834807-Receptor, Adenosine A2B, pubmed-meshheading:12834807-Receptor, Adenosine A3, pubmed-meshheading:12834807-Receptors, Adenosine A2, pubmed-meshheading:12834807-Receptors, Purinergic P1, pubmed-meshheading:12834807-Second Messenger Systems, pubmed-meshheading:12834807-Signal Transduction, pubmed-meshheading:12834807-Type C Phospholipases, pubmed-meshheading:12834807-p38 Mitogen-Activated Protein Kinases
pubmed:year
2003
pubmed:articleTitle
Signalling from adenosine receptors to mitogen-activated protein kinases.
pubmed:affiliation
Department of Physiology and Pharmacology, Karolinska Institutet, S-171 77, Stockholm, Sweden. gunnar.shulte@fyfa.kikse
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't