| pubmed-article:1282723 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1282723 | lifeskim:mentions | umls-concept:C1266872 | lld:lifeskim |
| pubmed-article:1282723 | lifeskim:mentions | umls-concept:C0063695 | lld:lifeskim |
| pubmed-article:1282723 | lifeskim:mentions | umls-concept:C0033634 | lld:lifeskim |
| pubmed-article:1282723 | lifeskim:mentions | umls-concept:C0333516 | lld:lifeskim |
| pubmed-article:1282723 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:1282723 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:1282723 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:1282723 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:1282723 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:1282723 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:1282723 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:1282723 | pubmed:dateCreated | 1993-2-11 | lld:pubmed |
| pubmed-article:1282723 | pubmed:abstractText | The regulation of intercellular adhesion molecule-1 (ICAM-1) expression by renal tubular epithelial cells (TEC) has been studied in vitro. ICAM-1 expression in TEC is stimulated with phorbol 12-myristate 13-acetate (PMA), but not with forskolin, suggesting a role for protein kinase C (PKC) but not for protein kinase A (PKA). The tumor necrosis factor-alpha- (TNF-alpha) and interleukin-1 (IL-1)-stimulated ICAM-1 expression in TEC is blocked with the PKC/PKA inhibitor staurosporine, and also with the PKC-selective inhibitor calphostin C. The TNF-alpha-stimulated ICAM-1 expression is resistant however to downregulation of PKC with PMA. The TNF-alpha- and IL-1-stimulated ICAM-1 expression is also inhibited with the transcriptional inhibitor actinomycin D and with the protein synthesis inhibitor cycloheximide. Thus, ICAM-1 expression by TEC may involve a downregulation-resistant PKC which induces ICAM-1 expression at a transcriptional level. | lld:pubmed |
| pubmed-article:1282723 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1282723 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1282723 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1282723 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1282723 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1282723 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1282723 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1282723 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1282723 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1282723 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1282723 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1282723 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1282723 | pubmed:issn | 1011-6524 | lld:pubmed |
| pubmed-article:1282723 | pubmed:author | pubmed-author:WuthrichR PRP | lld:pubmed |
| pubmed-article:1282723 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1282723 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:1282723 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1282723 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1282723 | pubmed:pagination | 302-6 | lld:pubmed |
| pubmed-article:1282723 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:1282723 | pubmed:meshHeading | pubmed-meshheading:1282723-... | lld:pubmed |
| pubmed-article:1282723 | pubmed:meshHeading | pubmed-meshheading:1282723-... | lld:pubmed |
| pubmed-article:1282723 | pubmed:meshHeading | pubmed-meshheading:1282723-... | lld:pubmed |
| pubmed-article:1282723 | pubmed:meshHeading | pubmed-meshheading:1282723-... | lld:pubmed |
| pubmed-article:1282723 | pubmed:meshHeading | pubmed-meshheading:1282723-... | lld:pubmed |
| pubmed-article:1282723 | pubmed:meshHeading | pubmed-meshheading:1282723-... | lld:pubmed |
| pubmed-article:1282723 | pubmed:meshHeading | pubmed-meshheading:1282723-... | lld:pubmed |
| pubmed-article:1282723 | pubmed:meshHeading | pubmed-meshheading:1282723-... | lld:pubmed |
| pubmed-article:1282723 | pubmed:meshHeading | pubmed-meshheading:1282723-... | lld:pubmed |
| pubmed-article:1282723 | pubmed:meshHeading | pubmed-meshheading:1282723-... | lld:pubmed |
| pubmed-article:1282723 | pubmed:meshHeading | pubmed-meshheading:1282723-... | lld:pubmed |
| pubmed-article:1282723 | pubmed:meshHeading | pubmed-meshheading:1282723-... | lld:pubmed |
| pubmed-article:1282723 | pubmed:meshHeading | pubmed-meshheading:1282723-... | lld:pubmed |
| pubmed-article:1282723 | pubmed:meshHeading | pubmed-meshheading:1282723-... | lld:pubmed |
| pubmed-article:1282723 | pubmed:meshHeading | pubmed-meshheading:1282723-... | lld:pubmed |
| pubmed-article:1282723 | pubmed:articleTitle | Tumor necrosis factor-alpha- and interleukin-1-stimulated intercellular adhesion molecule-1 expression by murine renal tubular epithelial cells is transcriptionally regulated and involves protein kinase C. | lld:pubmed |
| pubmed-article:1282723 | pubmed:affiliation | Division of Nephrology, University of Alabama, Birmingham 35294. | lld:pubmed |
| pubmed-article:1282723 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1282723 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1282723 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1282723 | lld:pubmed |
