| pubmed-article:12824054 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12824054 | lifeskim:mentions | umls-concept:C0600251 | lld:lifeskim |
| pubmed-article:12824054 | lifeskim:mentions | umls-concept:C0007785 | lld:lifeskim |
| pubmed-article:12824054 | lifeskim:mentions | umls-concept:C1537647 | lld:lifeskim |
| pubmed-article:12824054 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:12824054 | lifeskim:mentions | umls-concept:C0678951 | lld:lifeskim |
| pubmed-article:12824054 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:12824054 | pubmed:dateCreated | 2003-6-25 | lld:pubmed |
| pubmed-article:12824054 | pubmed:abstractText | Interleukin-1 (IL-1) has pleiotropic actions in the central nervous system. During the last decade, a growing corpus of evidence has indicated an important role of this cytokine in the development of brain damage following cerebral ischemia. The expression of IL-1 in the brain is dramatically increased during the early and chronic stage of infarction. The IL-1 gene cluster on chromosome 2q14 contains three related genes (IL1alpha, IL1beta, and IL1 receptor antagonist) located within a 430-kb region. T and C alleles exist for the IL-1alpha-889 regulatory region and the TT genotype has been reported to increase the production of the protein in lipopolysaccharide (LPS)-stimulated mononuclear cells from IL-1alpha-889 TT carriers. We examined whether the IL-1alpha polymorphism affects the probability of cerebral infarction (CI). We genotyped 360 CI patients and 519 healthy controls for the same polymorphism. A significant increase was found for the IL-1alpha T allele in CI patients compared with controls (chi2=5.026, P=0.025). We conclude that the IL-1alpha-889 polymorphism is a major risk factor for CI in Koreans. | lld:pubmed |
| pubmed-article:12824054 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12824054 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12824054 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12824054 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12824054 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12824054 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:12824054 | pubmed:issn | 0169-328X | lld:pubmed |
| pubmed-article:12824054 | pubmed:author | pubmed-author:KimHyung-MinH... | lld:pubmed |
| pubmed-article:12824054 | pubmed:author | pubmed-author:LeeKang-MinKM | lld:pubmed |
| pubmed-article:12824054 | pubmed:author | pubmed-author:MoonByung-Soo... | lld:pubmed |
| pubmed-article:12824054 | pubmed:author | pubmed-author:UmJae-YoungJY | lld:pubmed |
| pubmed-article:12824054 | pubmed:author | pubmed-author:ChoKwang-HoKH | lld:pubmed |
| pubmed-article:12824054 | pubmed:author | pubmed-author:MoonKyung-Suk... | lld:pubmed |
| pubmed-article:12824054 | pubmed:author | pubmed-author:YunJong-MinJM | lld:pubmed |
| pubmed-article:12824054 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12824054 | pubmed:day | 4 | lld:pubmed |
| pubmed-article:12824054 | pubmed:volume | 115 | lld:pubmed |
| pubmed-article:12824054 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12824054 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12824054 | pubmed:pagination | 50-4 | lld:pubmed |
| pubmed-article:12824054 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:12824054 | pubmed:meshHeading | pubmed-meshheading:12824054... | lld:pubmed |
| pubmed-article:12824054 | pubmed:meshHeading | pubmed-meshheading:12824054... | lld:pubmed |
| pubmed-article:12824054 | pubmed:meshHeading | pubmed-meshheading:12824054... | lld:pubmed |
| pubmed-article:12824054 | pubmed:meshHeading | pubmed-meshheading:12824054... | lld:pubmed |
| pubmed-article:12824054 | pubmed:meshHeading | pubmed-meshheading:12824054... | lld:pubmed |
| pubmed-article:12824054 | pubmed:meshHeading | pubmed-meshheading:12824054... | lld:pubmed |
| pubmed-article:12824054 | pubmed:meshHeading | pubmed-meshheading:12824054... | lld:pubmed |
| pubmed-article:12824054 | pubmed:meshHeading | pubmed-meshheading:12824054... | lld:pubmed |
| pubmed-article:12824054 | pubmed:meshHeading | pubmed-meshheading:12824054... | lld:pubmed |
| pubmed-article:12824054 | pubmed:meshHeading | pubmed-meshheading:12824054... | lld:pubmed |
| pubmed-article:12824054 | pubmed:meshHeading | pubmed-meshheading:12824054... | lld:pubmed |
| pubmed-article:12824054 | pubmed:meshHeading | pubmed-meshheading:12824054... | lld:pubmed |
| pubmed-article:12824054 | pubmed:meshHeading | pubmed-meshheading:12824054... | lld:pubmed |
| pubmed-article:12824054 | pubmed:meshHeading | pubmed-meshheading:12824054... | lld:pubmed |
| pubmed-article:12824054 | pubmed:meshHeading | pubmed-meshheading:12824054... | lld:pubmed |
| pubmed-article:12824054 | pubmed:meshHeading | pubmed-meshheading:12824054... | lld:pubmed |
| pubmed-article:12824054 | pubmed:meshHeading | pubmed-meshheading:12824054... | lld:pubmed |
| pubmed-article:12824054 | pubmed:meshHeading | pubmed-meshheading:12824054... | lld:pubmed |
| pubmed-article:12824054 | pubmed:meshHeading | pubmed-meshheading:12824054... | lld:pubmed |
| pubmed-article:12824054 | pubmed:meshHeading | pubmed-meshheading:12824054... | lld:pubmed |
| pubmed-article:12824054 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12824054 | pubmed:articleTitle | Association of interleukin-1 alpha gene polymorphism with cerebral infarction. | lld:pubmed |
| pubmed-article:12824054 | pubmed:affiliation | Department of Pharmacology, College of Oriental Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, South Korea. | lld:pubmed |
| pubmed-article:12824054 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12824054 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:3552 | entrezgene:pubmed | pubmed-article:12824054 | lld:entrezgene |
| entrez-gene:3553 | entrezgene:pubmed | pubmed-article:12824054 | lld:entrezgene |
| entrez-gene:3557 | entrezgene:pubmed | pubmed-article:12824054 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12824054 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12824054 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12824054 | lld:entrezgene |
