Source:http://linkedlifedata.com/resource/pubmed/id/12824054
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2003-6-25
|
| pubmed:abstractText |
Interleukin-1 (IL-1) has pleiotropic actions in the central nervous system. During the last decade, a growing corpus of evidence has indicated an important role of this cytokine in the development of brain damage following cerebral ischemia. The expression of IL-1 in the brain is dramatically increased during the early and chronic stage of infarction. The IL-1 gene cluster on chromosome 2q14 contains three related genes (IL1alpha, IL1beta, and IL1 receptor antagonist) located within a 430-kb region. T and C alleles exist for the IL-1alpha-889 regulatory region and the TT genotype has been reported to increase the production of the protein in lipopolysaccharide (LPS)-stimulated mononuclear cells from IL-1alpha-889 TT carriers. We examined whether the IL-1alpha polymorphism affects the probability of cerebral infarction (CI). We genotyped 360 CI patients and 519 healthy controls for the same polymorphism. A significant increase was found for the IL-1alpha T allele in CI patients compared with controls (chi2=5.026, P=0.025). We conclude that the IL-1alpha-889 polymorphism is a major risk factor for CI in Koreans.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0169-328X
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
4
|
| pubmed:volume |
115
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
50-4
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| pubmed:dateRevised |
2010-11-18
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| pubmed:meshHeading |
pubmed-meshheading:12824054-Adult,
pubmed-meshheading:12824054-Aged,
pubmed-meshheading:12824054-Brain Ischemia,
pubmed-meshheading:12824054-Cerebral Infarction,
pubmed-meshheading:12824054-Chromosome Mapping,
pubmed-meshheading:12824054-Chromosomes, Human, Pair 2,
pubmed-meshheading:12824054-Female,
pubmed-meshheading:12824054-Gene Frequency,
pubmed-meshheading:12824054-Genetic Linkage,
pubmed-meshheading:12824054-Genetic Predisposition to Disease,
pubmed-meshheading:12824054-Genetic Testing,
pubmed-meshheading:12824054-Genotype,
pubmed-meshheading:12824054-Humans,
pubmed-meshheading:12824054-Interleukin-1,
pubmed-meshheading:12824054-Korea,
pubmed-meshheading:12824054-Leukocytes, Mononuclear,
pubmed-meshheading:12824054-Male,
pubmed-meshheading:12824054-Middle Aged,
pubmed-meshheading:12824054-Polymorphism, Genetic,
pubmed-meshheading:12824054-Risk Factors
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
Association of interleukin-1 alpha gene polymorphism with cerebral infarction.
|
| pubmed:affiliation |
Department of Pharmacology, College of Oriental Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, South Korea.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|