| pubmed-article:12819013 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12819013 | lifeskim:mentions | umls-concept:C0040300 | lld:lifeskim |
| pubmed-article:12819013 | lifeskim:mentions | umls-concept:C0684249 | lld:lifeskim |
| pubmed-article:12819013 | lifeskim:mentions | umls-concept:C2239176 | lld:lifeskim |
| pubmed-article:12819013 | lifeskim:mentions | umls-concept:C0041904 | lld:lifeskim |
| pubmed-article:12819013 | lifeskim:mentions | umls-concept:C0162493 | lld:lifeskim |
| pubmed-article:12819013 | lifeskim:mentions | umls-concept:C1418406 | lld:lifeskim |
| pubmed-article:12819013 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:12819013 | pubmed:dateCreated | 2003-6-23 | lld:pubmed |
| pubmed-article:12819013 | pubmed:abstractText | ALG-2 was isolated in a screen for proteins involved in programmed cell death and is the first Ca(2+)-binding protein found to be directly involved in apoptosis. We have generated polyclonal antibodies that are suitable for detecting ALG-2 using different immunological methods. Three commercial antibodies against ALG-2 did neither detect mouse recombinant ALG-2 nor endogenous ALG-2 in Jurkat cell lysates, whereas our own affinity-purified antibody recognized recombinant as well as endogenous ALG-2. The specificity of the antibody was shown by preabsorbtion experiments and on ALG-2-deficient cells using Western blot analysis and immunohistochemistry. Western blot analysis of 15 different adult mouse tissues demonstrated that ALG-2 is ubiquitously expressed. We found that ALG-2 was more than threefold overexpressed in rat liver hepatoma compared to normal rat liver using Western blot analysis, a result confirmed by immunohistochemical analysis. Staining of four different lung cancer tissue microarrays including specimens of 263 patients showed that ALG-2 is mainly localized to epithelial cells and significantly up-regulated in small-cell lung cancers and in non-small-cell lung cancers. Our results lead to the conclusion that ALG-2 beside its known proapoptotic functions may be a player in survival pathways. | lld:pubmed |
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| pubmed-article:12819013 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12819013 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12819013 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:12819013 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12819013 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:12819013 | pubmed:issn | 0002-9440 | lld:pubmed |
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| pubmed-article:12819013 | pubmed:author | pubmed-author:BerchtoldMart... | lld:pubmed |
| pubmed-article:12819013 | pubmed:author | pubmed-author:TarabykinaSve... | lld:pubmed |
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| pubmed-article:12819013 | pubmed:author | pubmed-author:WindingPernil... | lld:pubmed |
| pubmed-article:12819013 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12819013 | pubmed:volume | 163 | lld:pubmed |
| pubmed-article:12819013 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12819013 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12819013 | pubmed:pagination | 81-9 | lld:pubmed |
| pubmed-article:12819013 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:12819013 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12819013 | pubmed:articleTitle | Up-regulation of ALG-2 in hepatomas and lung cancer tissue. | lld:pubmed |
| pubmed-article:12819013 | pubmed:affiliation | Department of Molecular Cell Biology, University of Copenhagen, Copenhagen, and the Department of Pathology, University Hospital, Copenhagen, Denmark. | lld:pubmed |
| pubmed-article:12819013 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12819013 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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