| pubmed-article:12818374 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12818374 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:12818374 | lifeskim:mentions | umls-concept:C0007452 | lld:lifeskim |
| pubmed-article:12818374 | lifeskim:mentions | umls-concept:C0025148 | lld:lifeskim |
| pubmed-article:12818374 | lifeskim:mentions | umls-concept:C0001629 | lld:lifeskim |
| pubmed-article:12818374 | lifeskim:mentions | umls-concept:C0521428 | lld:lifeskim |
| pubmed-article:12818374 | lifeskim:mentions | umls-concept:C1550278 | lld:lifeskim |
| pubmed-article:12818374 | lifeskim:mentions | umls-concept:C0671870 | lld:lifeskim |
| pubmed-article:12818374 | lifeskim:mentions | umls-concept:C1415502 | lld:lifeskim |
| pubmed-article:12818374 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:12818374 | lifeskim:mentions | umls-concept:C1156511 | lld:lifeskim |
| pubmed-article:12818374 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:12818374 | pubmed:dateCreated | 2003-6-23 | lld:pubmed |
| pubmed-article:12818374 | pubmed:abstractText | Orexin-A has recently been identified as a new hypothalamic peptide working as a mediator in the regulation of feeding behavior and sleep control. To determine the role of orexin-A in peripheral metabolic processes, we examined direct effects of orexin-A on catecholamine synthesis and secretion in cultured bovine adrenal medullary cells. Incubation of cells with orexin-A (100 pM) for 20 min caused a small but significant increase in 14C-catecholamine synthesis from [14C]tyrosine, but not from L-3,4-dihydroxyphenyl[3-14C]alanine. Orexin-A (100 pM) potentiated the stimulatory effects of acetylcholine (0.3 mM) on 14C-catecholamine synthesis. Orexin-A significantly increased tyrosine hydroxylase activity, which was evident at 1 pM and maximal at 100 pM. 4 beta-Phorbol-12 beta-myristate-13 alpha-acetate, an activator of protein kinase C, did not enhance the stimulatory effects of orexin-A on tyrosine hydroxylase activity, while H-7 and staurosporine, inhibitors of protein kinase C, nullified the effects of orexin-A. Orexin-A had little effect on catecholamine secretion from the cells. Orexin receptor 1 (OX(1)R) but not orexin receptor 2 (OX(2)R) mRNA was detected in bovine adrenal medullary cells by reverse transcriptase-polymerase chain reaction. These findings suggest that orexin-A activates tyrosine hydroxylase and then stimulates catecholamine synthesis, probably via activation of the OX(1)R-protein kinase C pathway in adrenal medullary cells. | lld:pubmed |
| pubmed-article:12818374 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12818374 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12818374 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12818374 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12818374 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12818374 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12818374 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12818374 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12818374 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12818374 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12818374 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12818374 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12818374 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12818374 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12818374 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12818374 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12818374 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12818374 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12818374 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:12818374 | pubmed:issn | 0006-2952 | lld:pubmed |
| pubmed-article:12818374 | pubmed:author | pubmed-author:UenoSusumuS | lld:pubmed |
| pubmed-article:12818374 | pubmed:author | pubmed-author:AsayamaKohtar... | lld:pubmed |
| pubmed-article:12818374 | pubmed:author | pubmed-author:TsutsuiMasato... | lld:pubmed |
| pubmed-article:12818374 | pubmed:author | pubmed-author:YanagiharaNob... | lld:pubmed |
| pubmed-article:12818374 | pubmed:author | pubmed-author:ToyohiraYumik... | lld:pubmed |
| pubmed-article:12818374 | pubmed:author | pubmed-author:ShirahataAkir... | lld:pubmed |
| pubmed-article:12818374 | pubmed:author | pubmed-author:TanakaKazumiK | lld:pubmed |
| pubmed-article:12818374 | pubmed:author | pubmed-author:UtsunomiyaKen... | lld:pubmed |
| pubmed-article:12818374 | pubmed:author | pubmed-author:KawadaYasusad... | lld:pubmed |
| pubmed-article:12818374 | pubmed:author | pubmed-author:MorisadaNaoya... | lld:pubmed |
| pubmed-article:12818374 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12818374 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:12818374 | pubmed:volume | 66 | lld:pubmed |
| pubmed-article:12818374 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12818374 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12818374 | pubmed:pagination | 141-7 | lld:pubmed |
| pubmed-article:12818374 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:12818374 | pubmed:meshHeading | pubmed-meshheading:12818374... | lld:pubmed |
| pubmed-article:12818374 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12818374 | pubmed:articleTitle | Stimulation of catecholamine synthesis by orexin-A in bovine adrenal medullary cells through orexin receptor 1. | lld:pubmed |
| pubmed-article:12818374 | pubmed:affiliation | Department of Pediatrics, University of Occupational and Environmental Health, School of Medicine, 1-1, Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan. | lld:pubmed |
| pubmed-article:12818374 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12818374 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
