| pubmed-article:12817010 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12817010 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:12817010 | lifeskim:mentions | umls-concept:C0023861 | lld:lifeskim |
| pubmed-article:12817010 | lifeskim:mentions | umls-concept:C0025919 | lld:lifeskim |
| pubmed-article:12817010 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:12817010 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:12817010 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:12817010 | lifeskim:mentions | umls-concept:C0020964 | lld:lifeskim |
| pubmed-article:12817010 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:12817010 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:12817010 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:12817010 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:12817010 | pubmed:dateCreated | 2003-6-20 | lld:pubmed |
| pubmed-article:12817010 | pubmed:abstractText | CD8(+) T cells are required for protective immunity against intracellular pathogens such as Listeria monocytogenes. In this study, we used class Ia MHC-deficient mice, which have a severe reduction in circulating CD8(+) T cells, to determine the protective capacity of class Ib MHC-restricted T cells during L. monocytogenes infection. The K(b-/-)D(b-/-) mutation was backcrossed onto a C.B10 (BALB/c congenic at H-2 locus with C57BL/10) background, because BALB/c mice are more susceptible to Listeria infection than other commonly studied mouse strains such as C57BL/6. C.B10 K(b-/-)D(b-/-) mice immunized with a sublethal dose of L. monocytogenes were fully protected against a subsequent lethal infection. Adoptive transfer of Listeria-immune splenocyte subsets into naive K(b-/-)D(b-/-) mice indicated that CD8(+) T cells were the major component of this protective immune response. A CD8(+) T cell line isolated from the spleen of a Listeria-infected class Ia MHC-deficient mouse was shown to specifically recognize Listeria-infected cells in vitro, as determined by IFN-gamma secretion and cytotoxicity assays. Adoptive transfer of this T cell line alone resulted in significant protection against L. monocytogenes challenge. These results suggest that even a limited number of class Ib MHC-restricted T cells are sufficient to generate the rapid recall response required for protection against secondary infection with L. monocytogenes. | lld:pubmed |
| pubmed-article:12817010 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12817010 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12817010 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12817010 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12817010 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:12817010 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12817010 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12817010 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12817010 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:12817010 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:12817010 | pubmed:author | pubmed-author:PloeghH LHL | lld:pubmed |
| pubmed-article:12817010 | pubmed:author | pubmed-author:StarnbachM... | lld:pubmed |
| pubmed-article:12817010 | pubmed:author | pubmed-author:D'OrazioS ESE | lld:pubmed |
| pubmed-article:12817010 | pubmed:author | pubmed-author:HalmeD GDG | lld:pubmed |
| pubmed-article:12817010 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12817010 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:12817010 | pubmed:volume | 171 | lld:pubmed |
| pubmed-article:12817010 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12817010 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12817010 | pubmed:pagination | 291-8 | lld:pubmed |
| pubmed-article:12817010 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:12817010 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12817010 | pubmed:articleTitle | Class Ia MHC-deficient BALB/c mice generate CD8+ T cell-mediated protective immunity against Listeria monocytogenes infection. | lld:pubmed |
| pubmed-article:12817010 | pubmed:affiliation | Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA. | lld:pubmed |
| pubmed-article:12817010 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12817010 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:12817010 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12817010 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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