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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2003-6-17
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pubmed:abstractText |
Tumor necrosis factor-alpha (TNF-alpha) plays a key role in the inflammatory response and pathogenesis of Crohn's disease (CD). TNF-alpha -308A polymorphism within the TNF-alpha gene promoter has been associated with enhanced TNF-alpha production in vitro. The aim of this study was to investigate the effect of TNF-alpha promoter polymorphism at -308 on the susceptibility and phenotypic expression of fistulizing CD.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0002-9270
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
98
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1101-6
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12809834-Acute-Phase Proteins,
pubmed-meshheading:12809834-Adolescent,
pubmed-meshheading:12809834-Adult,
pubmed-meshheading:12809834-Aged,
pubmed-meshheading:12809834-Case-Control Studies,
pubmed-meshheading:12809834-Crohn Disease,
pubmed-meshheading:12809834-Cutaneous Fistula,
pubmed-meshheading:12809834-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:12809834-Female,
pubmed-meshheading:12809834-Genetic Predisposition to Disease,
pubmed-meshheading:12809834-Genotype,
pubmed-meshheading:12809834-Humans,
pubmed-meshheading:12809834-Logistic Models,
pubmed-meshheading:12809834-Male,
pubmed-meshheading:12809834-Middle Aged,
pubmed-meshheading:12809834-Polymorphism, Genetic,
pubmed-meshheading:12809834-Promoter Regions, Genetic,
pubmed-meshheading:12809834-Rectal Fistula,
pubmed-meshheading:12809834-Tumor Necrosis Factor-alpha
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pubmed:year |
2003
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pubmed:articleTitle |
TNF-alpha -308A promoter polymorphism is associated with enhanced TNF-alpha production and inflammatory activity in Crohn's patients with fistulizing disease.
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pubmed:affiliation |
Department of Functional Biology, University of Oviedo, Oviedo, Spain.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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