Source:http://linkedlifedata.com/resource/pubmed/id/12802209
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
7
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pubmed:dateCreated |
2003-6-12
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pubmed:abstractText |
Microglia are believed to participate in the mediation of neurodegeneration through producing a variety of cytotoxic factors upon activation. Pharmacological intervention in microglial activation may therefore exert a neuroprotective effect. In exploring pharmacological agents that can affect microglial activation, we found in this study that triptolide possesses a powerful inhibitory influence over microglia. Pretreatment with triptolide was able to dose-dependently reduce the lipopolysaccharide (LPS)-induced nitrite accumulation and tumor necrosis factor-alpha and interleukin-1beta release from LPS-activated microglia as revealed by Griess reaction and ELISA, respectively. Triptolide reduced LPS-stimulated mRNA expression of all three inflammatory factors. The results obtained from this study demonstrate that triptolide can inhibit inflammatory responses of microglia to inflammatory stimulation via a mechanism involving the inhibition of the synthesis and release of inflammatory factors.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Diterpenes,
http://linkedlifedata.com/resource/pubmed/chemical/Epoxy Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Phenanthrenes,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/triptolide
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0959-4965
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
23
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1091-5
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:12802209-Animals,
pubmed-meshheading:12802209-Cells, Cultured,
pubmed-meshheading:12802209-Diterpenes,
pubmed-meshheading:12802209-Dose-Response Relationship, Drug,
pubmed-meshheading:12802209-Epoxy Compounds,
pubmed-meshheading:12802209-Interleukin-1,
pubmed-meshheading:12802209-Male,
pubmed-meshheading:12802209-Microglia,
pubmed-meshheading:12802209-Nitric Oxide,
pubmed-meshheading:12802209-Phenanthrenes,
pubmed-meshheading:12802209-Rats,
pubmed-meshheading:12802209-Rats, Sprague-Dawley,
pubmed-meshheading:12802209-Tumor Necrosis Factor-alpha
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pubmed:year |
2003
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pubmed:articleTitle |
Triptolide inhibits TNF-alpha, IL-1 beta and NO production in primary microglial cultures.
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pubmed:affiliation |
Neuroscience Research Institute, Peking University, Beijing, PR China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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