| pubmed-article:12796776 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12796776 | lifeskim:mentions | umls-concept:C0111208 | lld:lifeskim |
| pubmed-article:12796776 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:12796776 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:12796776 | lifeskim:mentions | umls-concept:C1427306 | lld:lifeskim |
| pubmed-article:12796776 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:12796776 | lifeskim:mentions | umls-concept:C2348205 | lld:lifeskim |
| pubmed-article:12796776 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:12796776 | pubmed:dateCreated | 2003-6-27 | lld:pubmed |
| pubmed-article:12796776 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12796776 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12796776 | pubmed:abstractText | During activation, T cells express receptors for receiving positive and negative costimulatory signals. Here we identify the B and T lymphocyte attenuator (BTLA), an immunoglobulin domain-containing glycoprotein with two immunoreceptor tyrosine-based inhibitory motifs. BTLA is not expressed by naive T cells, but it is induced during activation and remains expressed on T helper type 1 (T(H)1) but not T(H)2 cells. Crosslinking BTLA with antigen receptors induces its tyrosine phosphorylation and association with the Src homology domain 2 (SH2)-containing protein tyrosine phosphatases SHP-1 and SHP-2, and attenuates production of interleukin 2 (IL-2). BTLA-deficient T cells show increased proliferation, and BTLA-deficient mice have increased specific antibody responses and enhanced sensitivity to experimental autoimmune encephalomyelitis. B7x, a peripheral homolog of B7, is a ligand of BTLA. Thus, BTLA is a third inhibitory receptor on T lymphocytes with similarities to cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1). | lld:pubmed |
| pubmed-article:12796776 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12796776 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12796776 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12796776 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12796776 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12796776 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12796776 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12796776 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12796776 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12796776 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12796776 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12796776 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12796776 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12796776 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12796776 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12796776 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12796776 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12796776 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12796776 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12796776 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12796776 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12796776 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12796776 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:12796776 | pubmed:issn | 1529-2908 | lld:pubmed |
| pubmed-article:12796776 | pubmed:author | pubmed-author:FallarinoFran... | lld:pubmed |
| pubmed-article:12796776 | pubmed:author | pubmed-author:AllisonJames... | lld:pubmed |
| pubmed-article:12796776 | pubmed:author | pubmed-author:ZangXingxingX | lld:pubmed |
| pubmed-article:12796776 | pubmed:author | pubmed-author:MurphyKenneth... | lld:pubmed |
| pubmed-article:12796776 | pubmed:author | pubmed-author:RussellJohn... | lld:pubmed |
| pubmed-article:12796776 | pubmed:author | pubmed-author:WatanabeNorih... | lld:pubmed |
| pubmed-article:12796776 | pubmed:author | pubmed-author:SedyJohn RJR | lld:pubmed |
| pubmed-article:12796776 | pubmed:author | pubmed-author:YangJianfeiJ | lld:pubmed |
| pubmed-article:12796776 | pubmed:author | pubmed-author:MurphyTheresa... | lld:pubmed |
| pubmed-article:12796776 | pubmed:author | pubmed-author:GavrieliMayaM | lld:pubmed |
| pubmed-article:12796776 | pubmed:author | pubmed-author:LoftinSusan... | lld:pubmed |
| pubmed-article:12796776 | pubmed:author | pubmed-author:HurchlaMichel... | lld:pubmed |
| pubmed-article:12796776 | pubmed:author | pubmed-author:ZimmermanNata... | lld:pubmed |
| pubmed-article:12796776 | pubmed:author | pubmed-author:SimJuliaJ | lld:pubmed |
| pubmed-article:12796776 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12796776 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:12796776 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12796776 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12796776 | pubmed:pagination | 670-9 | lld:pubmed |
| pubmed-article:12796776 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:12796776 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12796776 | pubmed:articleTitle | BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. | lld:pubmed |
| pubmed-article:12796776 | pubmed:affiliation | Department of Pathology & Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, Box 8118, 660 South Euclid Avenue, St. Louis, Missouri 63110, USA. | lld:pubmed |
| pubmed-article:12796776 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12796776 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12796776 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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