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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2003-6-27
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pubmed:databankReference |
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pubmed:abstractText |
During activation, T cells express receptors for receiving positive and negative costimulatory signals. Here we identify the B and T lymphocyte attenuator (BTLA), an immunoglobulin domain-containing glycoprotein with two immunoreceptor tyrosine-based inhibitory motifs. BTLA is not expressed by naive T cells, but it is induced during activation and remains expressed on T helper type 1 (T(H)1) but not T(H)2 cells. Crosslinking BTLA with antigen receptors induces its tyrosine phosphorylation and association with the Src homology domain 2 (SH2)-containing protein tyrosine phosphatases SHP-1 and SHP-2, and attenuates production of interleukin 2 (IL-2). BTLA-deficient T cells show increased proliferation, and BTLA-deficient mice have increased specific antibody responses and enhanced sensitivity to experimental autoimmune encephalomyelitis. B7x, a peripheral homolog of B7, is a ligand of BTLA. Thus, BTLA is a third inhibitory receptor on T lymphocytes with similarities to cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1).
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Apoptosis Regulatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA-4 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Ctla4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoconjugates,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Pdcd1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Programmed Cell Death 1 Receptor,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatase...,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatase...,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatase...,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ptpn11 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Ptpn6 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/abatacept
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1529-2908
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pubmed:author |
pubmed-author:AllisonJames PJP,
pubmed-author:FallarinoFrancescaF,
pubmed-author:GavrieliMayaM,
pubmed-author:HurchlaMichelle AMA,
pubmed-author:LoftinSusan KSK,
pubmed-author:MurphyKenneth MKM,
pubmed-author:MurphyTheresa LTL,
pubmed-author:RussellJohn HJH,
pubmed-author:SedyJohn RJR,
pubmed-author:SimJuliaJ,
pubmed-author:WatanabeNorihikoN,
pubmed-author:YangJianfeiJ,
pubmed-author:ZangXingxingX,
pubmed-author:ZimmermanNatalieN
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pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
670-9
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:12796776-Amino Acid Sequence,
pubmed-meshheading:12796776-Animals,
pubmed-meshheading:12796776-Antigens, CD,
pubmed-meshheading:12796776-Antigens, CD80,
pubmed-meshheading:12796776-Antigens, Differentiation,
pubmed-meshheading:12796776-Antigens, Surface,
pubmed-meshheading:12796776-Apoptosis Regulatory Proteins,
pubmed-meshheading:12796776-CTLA-4 Antigen,
pubmed-meshheading:12796776-Encephalomyelitis, Autoimmune, Experimental,
pubmed-meshheading:12796776-Immunoconjugates,
pubmed-meshheading:12796776-Interleukin-2,
pubmed-meshheading:12796776-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:12796776-Lymphocyte Activation,
pubmed-meshheading:12796776-Mice,
pubmed-meshheading:12796776-Molecular Sequence Data,
pubmed-meshheading:12796776-Phosphorylation,
pubmed-meshheading:12796776-Programmed Cell Death 1 Receptor,
pubmed-meshheading:12796776-Protein Tyrosine Phosphatase, Non-Receptor Type 1,
pubmed-meshheading:12796776-Protein Tyrosine Phosphatase, Non-Receptor Type 11,
pubmed-meshheading:12796776-Protein Tyrosine Phosphatase, Non-Receptor Type 6,
pubmed-meshheading:12796776-Protein Tyrosine Phosphatases,
pubmed-meshheading:12796776-Proteins,
pubmed-meshheading:12796776-RNA, Messenger,
pubmed-meshheading:12796776-Receptors, Immunologic,
pubmed-meshheading:12796776-T-Lymphocytes
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pubmed:year |
2003
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pubmed:articleTitle |
BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1.
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pubmed:affiliation |
Department of Pathology & Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, Box 8118, 660 South Euclid Avenue, St. Louis, Missouri 63110, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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