Source:http://linkedlifedata.com/resource/pubmed/id/12795791
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2003-6-10
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| pubmed:abstractText |
Tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) participate in the establishment of inflammatory lesions in periodontitis. High production of these cytokines may relate to the severity of periodontitis. There have already been several studies examining the association between periodontitis and single nucleotide polymorphisms (SNPs) that affect cytokine productivity. Recently, new SNPs of TNF-alpha, -1031, -863 and -857, variants of which are observed in a relatively large proportion in Japanese, have been identified. The variant alleles of these SNPs have been suggested to be related to high TNF-alpha production. For a better understanding of the genetic factors associated with the severity of periodontitis, further analysis including these newly identified SNPs is essential. In addition, previous reports on TNF-alpha or IL-1beta SNPs associated with periodontitis were mainly for Caucasian populations. Therefore, the aim of this study is to examine the association between severe periodontitis in Japanese and the following SNPs: five in the TNF-alpha gene promoter (-1031, -863, -857, -308, -238) and three in the IL-1beta gene (-511, -31, +3953).
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
D
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
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| pubmed:issn |
0303-6979
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
30
|
| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
524-31
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:12795791-Alleles,
pubmed-meshheading:12795791-Asian Continental Ancestry Group,
pubmed-meshheading:12795791-Case-Control Studies,
pubmed-meshheading:12795791-Female,
pubmed-meshheading:12795791-Gene Frequency,
pubmed-meshheading:12795791-Humans,
pubmed-meshheading:12795791-Interleukin-1,
pubmed-meshheading:12795791-Japan,
pubmed-meshheading:12795791-Linkage Disequilibrium,
pubmed-meshheading:12795791-Male,
pubmed-meshheading:12795791-Middle Aged,
pubmed-meshheading:12795791-Monocytes,
pubmed-meshheading:12795791-Periodontitis,
pubmed-meshheading:12795791-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:12795791-Polymorphism, Single Nucleotide,
pubmed-meshheading:12795791-Promoter Regions, Genetic,
pubmed-meshheading:12795791-Severity of Illness Index,
pubmed-meshheading:12795791-Tumor Necrosis Factor-alpha
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
Tumor necrosis factor-alpha gene (TNF-alpha) -1031/-863, -857 single-nucleotide polymorphisms (SNPs) are associated with severe adult periodontitis in Japanese.
|
| pubmed:affiliation |
Department of Patho-physiology/Periodontal Science, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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