Linked Life Data

12794762

Source:http://linkedlifedata.com/resource/pubmed/id/12794762

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2003-6-9
pubmed:abstractText
Higher levels of circulating Insulin-like Growth Factor (IGF)-I may be associated with higher risks for premenopausal breast cancer. We investigate the associations between circulating levels of IGF-I, its binding proteins (IGFBPs) -1, -2, -3, C-peptide and postmenopausal breast cancer. This is a prospective study nested in 2 Dutch cohorts. The study population included women who were postmenopausal at baseline. Breast cancer cases were identified through linkage with cancer registries. Controls were matched to cases by cohort, age, date of blood donation and place of residence. In total, 149 breast cancer cases and 333 healthy controls were included. Plasma levels of IGF-I, IGFBP-1, -2, -3 and C-peptide were measured by radioimmunoassays. Estimates of the relative risk for breast cancer associated with the quartiles of the peptides' circulating levels were obtained by conditional logistic regression. Models were adjusted for BMI, age at menarche and age at first full-term delivery. For IGF-I, the adjusted OR (95% CI) of the top vs. bottom quartile was 1.1 (0.6; 2.1); for IGFBP-1 it was 0.7 (0.3; 1.3); for IGFBP-2, 1.1 (0.5; 2.4); for IGFBP-3, 1.6 (0.7; 3.5), for C-peptide, 1.3 (0.7; 2.7) and for IGF-I/IGFBP-3 ratio, 1.0 (0.5; 1.8). Our data do not support an association between postmenopausal circulating levels of IGF-I, IGFBP-1, -2, -3, C-peptide and postmenopausal breast cancer.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0020-7136
pubmed:author
pubmed:copyrightInfo
Copyright 2003 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
106
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
90-5
pubmed:dateRevised
2007-7-24
pubmed:meshHeading
pubmed-meshheading:12794762-Aged, pubmed-meshheading:12794762-Apoptosis, pubmed-meshheading:12794762-Breast Neoplasms, pubmed-meshheading:12794762-C-Peptide, pubmed-meshheading:12794762-Cohort Studies, pubmed-meshheading:12794762-Female, pubmed-meshheading:12794762-Humans, pubmed-meshheading:12794762-Insulin-Like Growth Factor Binding Protein 1, pubmed-meshheading:12794762-Insulin-Like Growth Factor Binding Protein 2, pubmed-meshheading:12794762-Insulin-Like Growth Factor Binding Protein 3, pubmed-meshheading:12794762-Insulin-Like Growth Factor I, pubmed-meshheading:12794762-Middle Aged, pubmed-meshheading:12794762-Odds Ratio, pubmed-meshheading:12794762-Postmenopause, pubmed-meshheading:12794762-Prospective Studies, pubmed-meshheading:12794762-Registries, pubmed-meshheading:12794762-Risk Factors
pubmed:year
2003
pubmed:articleTitle
Circulating levels of insulin-like growth factor I, its binding proteins -1,-2, -3, C-peptide and risk of postmenopausal breast cancer.
pubmed:affiliation
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht (UMCU), Utrecht, The Netherlands. L.K.Boker@jc.azu.nl
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't