Linked Life Data

12783785

Source:http://linkedlifedata.com/resource/pubmed/id/12783785

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
14
pubmed:dateCreated
2003-6-4
pubmed:abstractText
Wingless directs many developmental processes in Drosophila by regulating expression of specific target genes through a conserved signaling pathway. Although many nuclear factors have been implicated in mediating Wingless-induced transcription, the mechanism of how Wingless regulates different targets in different tissues remains poorly understood. We report here that the split ends gene is required for Wingless signaling in the eye, wing and leg imaginal discs. Expression of a dominant-negative version of split ends resulted in more dramatic reductions in Wingless signaling than split ends-null alleles, suggesting that it may have a redundant partner. However, removal of split ends or expression of the dominant-negative had no effect on several Wingless signaling readouts in the embryo. The expression pattern of Split ends cannot explain this tissue-specific requirement, as the protein is predominantly nuclear and present throughout embryogenesis and larval tissues. Consistent with its nuclear location, the split ends dominant-negative acts downstream of Armadillo stabilization. Our data indicate that Split ends is an important positive regulator of Wingless signaling in larval tissues. However, it has no detectable role in the embryonic Wingless pathway, suggesting that it is a tissue or promoter-specific factor.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0950-1991
pubmed:author
pubmed:issnType
Print
pubmed:volume
130
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3125-35
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:12783785-Alleles, pubmed-meshheading:12783785-Animals, pubmed-meshheading:12783785-Cell Nucleus, pubmed-meshheading:12783785-Drosophila Proteins, pubmed-meshheading:12783785-Drosophila melanogaster, pubmed-meshheading:12783785-Genes, Dominant, pubmed-meshheading:12783785-Homeodomain Proteins, pubmed-meshheading:12783785-Microscopy, Electron, Scanning, pubmed-meshheading:12783785-Microscopy, Fluorescence, pubmed-meshheading:12783785-Mutation, pubmed-meshheading:12783785-Nuclear Proteins, pubmed-meshheading:12783785-Phenotype, pubmed-meshheading:12783785-Photoreceptor Cells, Invertebrate, pubmed-meshheading:12783785-Promoter Regions, Genetic, pubmed-meshheading:12783785-Proto-Oncogene Proteins, pubmed-meshheading:12783785-Signal Transduction, pubmed-meshheading:12783785-Wnt1 Protein
pubmed:year
2003
pubmed:articleTitle
Splits ends is a tissue/promoter specific regulator of Wingless signaling.
pubmed:affiliation
Department of Molecular, Cellular and Developmental Biology, University of Michigan, Natural Science Building, Ann Arbor, MI 48109, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't