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rdf:type |
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lifeskim:mentions |
umls-concept:C0005390,
umls-concept:C0007634,
umls-concept:C0010453,
umls-concept:C0017262,
umls-concept:C0031354,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0205263,
umls-concept:C0441712,
umls-concept:C0596263,
umls-concept:C1168250,
umls-concept:C1267213,
umls-concept:C1565860,
umls-concept:C2911684
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pubmed:issue |
6
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|
pubmed:dateCreated |
2003-6-3
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pubmed:abstractText |
Laryngopharyngeal reflux is a common event in patients with head and neck cancer. Bile acid is known to be related to tumor formation in the esophagus through the overexpression of cyclo-oxygenase-2 (COX-2), an enzyme that produces prostanoids. To better understand the mechanism of the laryngopharyngeal reflux-cancer connection, we examined COX-2 expression by bile acid in cultured human pharyngeal mucosa cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0023-852X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
113
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1059-63
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12782823-Bile Acids and Salts,
pubmed-meshheading:12782823-Cell Transformation, Neoplastic,
pubmed-meshheading:12782823-Chenodeoxycholic Acid,
pubmed-meshheading:12782823-Cyclooxygenase 2,
pubmed-meshheading:12782823-Dactinomycin,
pubmed-meshheading:12782823-Dose-Response Relationship, Drug,
pubmed-meshheading:12782823-Enzyme Induction,
pubmed-meshheading:12782823-Esophageal Neoplasms,
pubmed-meshheading:12782823-Gastroesophageal Reflux,
pubmed-meshheading:12782823-Humans,
pubmed-meshheading:12782823-Isoenzymes,
pubmed-meshheading:12782823-Laryngeal Neoplasms,
pubmed-meshheading:12782823-Larynx,
pubmed-meshheading:12782823-Membrane Proteins,
pubmed-meshheading:12782823-Pharyngeal Neoplasms,
pubmed-meshheading:12782823-Pharynx,
pubmed-meshheading:12782823-Promoter Regions, Genetic,
pubmed-meshheading:12782823-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:12782823-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:12782823-Transcription, Genetic,
pubmed-meshheading:12782823-Tumor Cells, Cultured
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pubmed:year |
2003
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pubmed:articleTitle |
Bile acid induces cyclo-oxygenase-2 expression in cultured human pharyngeal cells: a possible mechanism of carcinogenesis in the upper aerodigestive tract by laryngopharyngeal reflux.
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pubmed:affiliation |
Department of Otolaryngology-Head and Neck Surgery, Seoul National University College of Medicine, Chongno-Gu, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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