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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2003-5-30
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pubmed:abstractText |
Understanding the mechanisms through which multicellular organisms regulate cell, organ and body growth is of relevance to developmental biology and to research on growth-related diseases such as cancer. Here we describe a new effector in growth control, the small GTPase Rheb (Ras homologue enriched in brain). Mutations in the Drosophila melanogaster Rheb gene were isolated as growth-inhibitors, whereas overexpression of Rheb promoted cell growth. Our genetic and biochemical analyses suggest that Rheb functions downstream of the tumour suppressors Tsc1 (tuberous sclerosis 1)-Tsc2 in the TOR (target of rapamycin) signalling pathway to control growth, and that a major effector of Rheb function is ribosomal S6 kinase (S6K).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1465-7392
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
559-65
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12766775-Animals,
pubmed-meshheading:12766775-Cell Division,
pubmed-meshheading:12766775-Cell Size,
pubmed-meshheading:12766775-Drosophila Proteins,
pubmed-meshheading:12766775-Drosophila melanogaster,
pubmed-meshheading:12766775-Eye,
pubmed-meshheading:12766775-Female,
pubmed-meshheading:12766775-Gene Deletion,
pubmed-meshheading:12766775-Genes, Insect,
pubmed-meshheading:12766775-Genes, Tumor Suppressor,
pubmed-meshheading:12766775-Growth Substances,
pubmed-meshheading:12766775-Monomeric GTP-Binding Proteins,
pubmed-meshheading:12766775-Neuropeptides,
pubmed-meshheading:12766775-Recombinant Fusion Proteins,
pubmed-meshheading:12766775-Repressor Proteins,
pubmed-meshheading:12766775-Ribosomal Protein S6 Kinases,
pubmed-meshheading:12766775-Signal Transduction,
pubmed-meshheading:12766775-Transcriptional Activation,
pubmed-meshheading:12766775-Transgenes
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pubmed:year |
2003
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pubmed:articleTitle |
Rheb is an essential regulator of S6K in controlling cell growth in Drosophila.
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pubmed:affiliation |
Zoologisches Institut der Universität Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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