Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13
pubmed:dateCreated
2003-5-20
pubmed:abstractText
The Drosophila heart consists of two major cell types: cardioblasts, which form the contractile tube of the heart; and pericardial cells, which flank the cardioblasts and are thought to filter and detoxify the blood or hemolymph of the fly. We present the completion of the entire cell lineage of all heart cells. Notably, we detect a previously unappreciated distinction between the lineages of heart cells located in the posterior seven segments relative to those located more anteriorly. Using a genetic screen, we have identified the ETS-transcription factor pointed as a key regulator of cardioblast and pericardial cell fates in the posterior seven segments of the heart. In this domain, pointed promotes pericardial cell development and opposes cardioblast development. We find that this function of pointed is carried out primarily if not exclusively by the pointedP2 isoform and, that in this context, pointedP2 may act independently of Ras/MAPK pathway activity. We go on to show that the GATA transcription factor pannier acts early in dorsal mesoderm development to promote the development of the cardiac mesoderm and thus all heart cells. Finally, we demonstrate that pannier acts upstream of pointed in a developmental pathway in which pannier promotes cardiac mesoderm formation, and pointed acts subsequently in this domain to distinguish between cardioblast and pericardial cell fates.
pubmed:keyword
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Protein Isoforms, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators, http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors, http://linkedlifedata.com/resource/pubmed/chemical/eve protein, Drosophila, http://linkedlifedata.com/resource/pubmed/chemical/pnr protein, Drosophila, http://linkedlifedata.com/resource/pubmed/chemical/pnt protein, Drosophila, http://linkedlifedata.com/resource/pubmed/chemical/ras Proteins, http://linkedlifedata.com/resource/pubmed/chemical/tin protein, Drosophila
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0950-1991
pubmed:author
pubmed:issnType
Print
pubmed:volume
130
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3015-26
pubmed:dateRevised
2008-10-15
pubmed:meshHeading
pubmed-meshheading:12756183-Animals, pubmed-meshheading:12756183-Cell Differentiation, pubmed-meshheading:12756183-Cell Lineage, pubmed-meshheading:12756183-DNA-Binding Proteins, pubmed-meshheading:12756183-Drosophila Proteins, pubmed-meshheading:12756183-Drosophila melanogaster, pubmed-meshheading:12756183-Gene Expression Regulation, Developmental, pubmed-meshheading:12756183-Genes, Insect, pubmed-meshheading:12756183-Heart, pubmed-meshheading:12756183-Homeodomain Proteins, pubmed-meshheading:12756183-Mesoderm, pubmed-meshheading:12756183-Models, Biological, pubmed-meshheading:12756183-Nerve Tissue Proteins, pubmed-meshheading:12756183-Protein Isoforms, pubmed-meshheading:12756183-Proto-Oncogene Proteins, pubmed-meshheading:12756183-RNA Interference, pubmed-meshheading:12756183-Repressor Proteins, pubmed-meshheading:12756183-Trans-Activators, pubmed-meshheading:12756183-Transcription Factors, pubmed-meshheading:12756183-ras Proteins
pubmed:year
2003
pubmed:articleTitle
pannier and pointedP2 act sequentially to regulate Drosophila heart development.
pubmed:affiliation
Department of Genetics, Washington University School of Medicine, 4566 Scott Avenue, St Louis, MO 63110, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.