Linked Life Data

12749926

Source:http://linkedlifedata.com/resource/pubmed/id/12749926

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2003-5-16
pubmed:abstractText
In recent years, the use of microbubble ultrasound (US) contrast agents as carriers in drug and gene delivery applications has intensified the need for a clear understanding of the processes involved in their destruction. In this study, an analysis of the conditions in the shell of a contrast agent particle has been made, based on the full numerical solution of a modified Rayleigh-Plesset equation. The results indicate that extremely high shell stresses may be expected under typical clinical conditions. Examination of previous experimental evidence in the light of these findings suggests that the shells are almost invariably disrupted, even if they are not visibly destroyed. This has some serious implications, both for targeted delivery processes and reliable assessment of the potential for harmful bioeffects. At present, neither the model nor the experimental data provide an adequate description of contrast agent behaviour. This is due primarily to the lack of information regarding the mechanical response of the shell material and the restriction of the model to the case of small, spherically symmetrical oscillations. Methods for addressing these deficiencies in future work are proposed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0301-5629
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
563-73
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
On the destruction of microbubble ultrasound contrast agents.
pubmed:affiliation
Department of Mechanical Engineering, University College London, London, UK. e_stride@meng.ucl.ac.uk
pubmed:publicationType
Journal Article