|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
28
|
|
pubmed:dateCreated |
2003-7-4
|
|
pubmed:abstractText |
Cells dividing at the time of carcinogen exposure are at particular risk for neoplasia. Tobacco smoke contains numerous carcinogens, and we find that smoke, in the absence of exogenous growth factors, is capable of stimulating cell proliferation. The smoke-triggered mechanism includes the generation of oxygen radicals, which in turn stimulate tumor necrosis factor alpha-converting enzyme (a disintegrin and metalloproteinase (ADAM) 17) to cleave transmembrane amphiregulin, a ligand for the epidermal growth factor receptor (EGFR). The binding of amphiregulin to EGFR then stimulates proliferation of lung epithelial cells. These results shed light on the pathogenesis of lung cancer, suggest novel drug targets for the reduction of cancer risk in smokers, and provide insight into how EGFR integrates responses to diverse noxious stimuli.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ADAM Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Carcinogens,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Metalloendopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/Oligonucleotides, Antisense,
http://linkedlifedata.com/resource/pubmed/chemical/Oxygen,
http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/amphiregulin,
http://linkedlifedata.com/resource/pubmed/chemical/tumor necrosis factor-alpha...
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0021-9258
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
11
|
|
pubmed:volume |
278
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
26202-7
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:12711607-ADAM Proteins,
pubmed-meshheading:12711607-Animals,
pubmed-meshheading:12711607-Carcinogens,
pubmed-meshheading:12711607-Cell Division,
pubmed-meshheading:12711607-Cell Line,
pubmed-meshheading:12711607-Cells, Cultured,
pubmed-meshheading:12711607-Dose-Response Relationship, Drug,
pubmed-meshheading:12711607-Epithelial Cells,
pubmed-meshheading:12711607-Glycoproteins,
pubmed-meshheading:12711607-Humans,
pubmed-meshheading:12711607-Immunoblotting,
pubmed-meshheading:12711607-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:12711607-Ligands,
pubmed-meshheading:12711607-Lung,
pubmed-meshheading:12711607-Lung Neoplasms,
pubmed-meshheading:12711607-Metalloendopeptidases,
pubmed-meshheading:12711607-Mice,
pubmed-meshheading:12711607-Mice, Inbred C57BL,
pubmed-meshheading:12711607-Microscopy, Fluorescence,
pubmed-meshheading:12711607-Models, Biological,
pubmed-meshheading:12711607-Oligonucleotides, Antisense,
pubmed-meshheading:12711607-Oxygen,
pubmed-meshheading:12711607-Phosphorylation,
pubmed-meshheading:12711607-Precipitin Tests,
pubmed-meshheading:12711607-Protein Binding,
pubmed-meshheading:12711607-Reactive Oxygen Species,
pubmed-meshheading:12711607-Receptor, Epidermal Growth Factor,
pubmed-meshheading:12711607-Smoking,
pubmed-meshheading:12711607-Tumor Cells, Cultured
|
|
pubmed:year |
2003
|
|
pubmed:articleTitle |
Tobacco smoke-induced lung cell proliferation mediated by tumor necrosis factor alpha-converting enzyme and amphiregulin.
|
|
pubmed:affiliation |
Biomedical Sciences Program, Cardiovascular Research Institute and Department of Anatomy, University of California, San Francisco, California 94143, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
