|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5618
|
|
pubmed:dateCreated |
2003-4-18
|
|
pubmed:abstractText |
Insulin receptors are abundant in the central nervous system, but their roles remain elusive. Here we show that the insulin receptor functions in axon guidance. The Drosophila insulin receptor (DInR) is required for photoreceptor-cell (R-cell) axons to find their way from the retina to the brain during development of the visual system. DInR functions as a guidance receptor for the adapter protein Dock/Nck. This function is independent of Chico, the Drosophila insulin receptor substrate (IRS) homolog.
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/InR protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/chico protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/dreadlocks protein, Drosophila
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
1095-9203
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
18
|
|
pubmed:volume |
300
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
502-5
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:12702880-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:12702880-Animals,
pubmed-meshheading:12702880-Axons,
pubmed-meshheading:12702880-Binding Sites,
pubmed-meshheading:12702880-Blotting, Western,
pubmed-meshheading:12702880-Brain,
pubmed-meshheading:12702880-Carrier Proteins,
pubmed-meshheading:12702880-Cell Differentiation,
pubmed-meshheading:12702880-Cell Size,
pubmed-meshheading:12702880-Drosophila,
pubmed-meshheading:12702880-Drosophila Proteins,
pubmed-meshheading:12702880-Eye,
pubmed-meshheading:12702880-Female,
pubmed-meshheading:12702880-Growth Cones,
pubmed-meshheading:12702880-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:12702880-Male,
pubmed-meshheading:12702880-Mutation,
pubmed-meshheading:12702880-Nerve Tissue Proteins,
pubmed-meshheading:12702880-Photoreceptor Cells, Invertebrate,
pubmed-meshheading:12702880-Precipitin Tests,
pubmed-meshheading:12702880-Protein-Tyrosine Kinases,
pubmed-meshheading:12702880-Receptor, Insulin,
pubmed-meshheading:12702880-Receptor Protein-Tyrosine Kinases,
pubmed-meshheading:12702880-Retina,
pubmed-meshheading:12702880-Signal Transduction,
pubmed-meshheading:12702880-Two-Hybrid System Techniques,
pubmed-meshheading:12702880-Visual Pathways,
pubmed-meshheading:12702880-src Homology Domains
|
|
pubmed:year |
2003
|
|
pubmed:articleTitle |
Axons guided by insulin receptor in Drosophila visual system.
|
|
pubmed:affiliation |
Brookdale Department for Molecular, Cell, and Developmental Biology, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
