Linked Life Data

12700130

Source:http://linkedlifedata.com/resource/pubmed/id/12700130

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2003-4-17
pubmed:abstractText
Focal adhesion kinase (FAK) and its related kinase, proline rich tyrosine kinase 2 (PYK2), are major kinases activated by cell-extracellular matrix adhesion. Although they are highly expressed in the nervous system, the functions of these two kinases in the nervous system remained unclear until recently. FAK and PYK2 appear to play an important role in developing nervous system as well as adult brain. Importantly the two kinases are activated by different extracellular stimuli and execute distinct regulatory effects on various aspects of neural developmental processes and neuronal function. This review summarizes the potential roles of FAK and PYK2 in axon path-finding and synaptic plasticity.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1093-4715
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
s676-82
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Roles of FAK family kinases in nervous system.
pubmed:affiliation
Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. wxiong@path.uab.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review