Linked Life Data

12688339

Source:http://linkedlifedata.com/resource/pubmed/id/12688339

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2003-4-11
pubmed:abstractText
Cyclin-dependent kinase 5 (Cdk5) and its activator p35Nck5a are an odd but interesting couple. Recent work has established that in spite of their names, Cdk5 is clearly not cyclin-dependent, while p35Nck5a is not exclusively neuronal. Indeed, p35Nck5a and/or Cdk5 activity has been demonstrated to be present in human and rat promyelocytic cell lines, and in normal human monocytes. Further, monocytes from mice in which p35Nck5a gene was deleted do not express non-specific esterase, an enzyme present in normal monocytes, while transfection of Cdk5 together with p35Nck5a into myeloblastic cells leads to the expression of this marker of the monocytic phenotype. Thus, the Cdk5/p35Nck5a complex appears to play an important role in monocytic differentiation.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1042-8194
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
235-40
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
The neuronal cyclin-dependent kinase 5 activator p35Nck5a and Cdk5 activity in monocytic cells.
pubmed:affiliation
Department of Pathology and Laboratory Medicine, UMDNJ-New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA. studzins@umdnj.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review