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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2003-4-9
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pubmed:abstractText |
Canine malignant melanoma (CMM) is a spontaneous, aggressive, and metastatic neoplasm. Preclinical mouse studies have shown that xenogeneic DNA vaccination with genes encoding tyrosinase family members can induce antibody and cytotoxic T-cell responses, resulting in tumor rejection. These studies provided the rationale for a trial of xenogeneic DNA vaccination in CMM using the human tyrosinase gene.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:BergmanPhilip JPJ,
pubmed-author:CharneySarahS,
pubmed-author:CraftDianeD,
pubmed-author:EngelhornManuelM,
pubmed-author:FarrellyJohnJ,
pubmed-author:GregorPollyP,
pubmed-author:HohenhausAnn EAE,
pubmed-author:HoughtonAlan NAN,
pubmed-author:JeffersYusufY,
pubmed-author:McKnightJoanneJ,
pubmed-author:NovosadAndrewA,
pubmed-author:RiviereIsabelleI,
pubmed-author:SadelainMichelM,
pubmed-author:SegalNeilN,
pubmed-author:WolchokJedd DJD,
pubmed-author:WulderkMichelleM
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1284-90
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12684396-Animals,
pubmed-meshheading:12684396-Cancer Vaccines,
pubmed-meshheading:12684396-Cohort Studies,
pubmed-meshheading:12684396-DNA, Complementary,
pubmed-meshheading:12684396-Dogs,
pubmed-meshheading:12684396-Female,
pubmed-meshheading:12684396-Humans,
pubmed-meshheading:12684396-Immunotherapy,
pubmed-meshheading:12684396-Male,
pubmed-meshheading:12684396-Melanoma,
pubmed-meshheading:12684396-Monophenol Monooxygenase,
pubmed-meshheading:12684396-Plasmids,
pubmed-meshheading:12684396-Radiography, Thoracic,
pubmed-meshheading:12684396-Time Factors,
pubmed-meshheading:12684396-Vaccines, DNA
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pubmed:year |
2003
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pubmed:articleTitle |
Long-term survival of dogs with advanced malignant melanoma after DNA vaccination with xenogeneic human tyrosinase: a phase I trial.
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pubmed:affiliation |
Donaldson-Atwood Cancer Clinic and Flaherty Comparative Oncology Laboratory, The E&M Bobst Hospital of the Animal Medical Center, New York, New York 10021, USA. Philip.bergman@amcny.org
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Clinical Trial, Phase I
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