| pubmed-article:12682259 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12682259 | lifeskim:mentions | umls-concept:C0330390 | lld:lifeskim |
| pubmed-article:12682259 | lifeskim:mentions | umls-concept:C0012634 | lld:lifeskim |
| pubmed-article:12682259 | lifeskim:mentions | umls-concept:C0014038 | lld:lifeskim |
| pubmed-article:12682259 | lifeskim:mentions | umls-concept:C0025919 | lld:lifeskim |
| pubmed-article:12682259 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:12682259 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:12682259 | lifeskim:mentions | umls-concept:C0332325 | lld:lifeskim |
| pubmed-article:12682259 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:12682259 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:12682259 | pubmed:dateCreated | 2003-4-8 | lld:pubmed |
| pubmed-article:12682259 | pubmed:abstractText | BALB/c are genetically resistant to development of toxoplasmic encephalitis (TE) when infected with Toxoplasma gondii, whereas CBA/Ca mice are susceptible. We compared TCR Vbeta chain usage in lymphocytes infiltrated into brains between these animals following infection. TCR Vbeta8(+) cells were the most frequent T cell population in brains of infected, resistant BALB/c mice, whereas TCR Vbeta6(+) T cells were more prevalent than Vbeta8(+) T cells in brains of infected, susceptible CBA/Ca mice. Adoptive transfer of Vbeta8(+) immune T cells, obtained from infected BALB/c mice, prevented development of TE and mortality in infected athymic nude mice that lack T cells. In contrast, adoptive transfer of Vbeta6(+) immune T cells did not prevent development of TE or mortality in the nude mice. The protective activity of Vbeta8(+) immune T cells was greater than that of the total Vbeta8(-) population. In addition, Vbeta8(+) immune T cells produced markedly greater amounts of IFN-gamma than did the Vbeta8(-) population after stimulation with tachyzoite lysate Ags in vitro. Thus, Vbeta8(+) T cells appear to play a crucial role in the genetic resistance of BALB/c mice against development of TE. | lld:pubmed |
| pubmed-article:12682259 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12682259 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12682259 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12682259 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12682259 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:12682259 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12682259 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12682259 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12682259 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12682259 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:12682259 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:12682259 | pubmed:author | pubmed-author:SuzukiYasuhir... | lld:pubmed |
| pubmed-article:12682259 | pubmed:author | pubmed-author:LiesenfeldOli... | lld:pubmed |
| pubmed-article:12682259 | pubmed:author | pubmed-author:KangHoilH | lld:pubmed |
| pubmed-article:12682259 | pubmed:author | pubmed-author:RemingtonJack... | lld:pubmed |
| pubmed-article:12682259 | pubmed:author | pubmed-author:ClaflinJennif... | lld:pubmed |
| pubmed-article:12682259 | pubmed:author | pubmed-author:WangXishengX | lld:pubmed |
| pubmed-article:12682259 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12682259 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:12682259 | pubmed:volume | 170 | lld:pubmed |
| pubmed-article:12682259 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12682259 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12682259 | pubmed:pagination | 4254-9 | lld:pubmed |
| pubmed-article:12682259 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:12682259 | pubmed:meshHeading | pubmed-meshheading:12682259... | lld:pubmed |
| pubmed-article:12682259 | pubmed:meshHeading | pubmed-meshheading:12682259... | lld:pubmed |
| pubmed-article:12682259 | pubmed:meshHeading | pubmed-meshheading:12682259... | lld:pubmed |
| pubmed-article:12682259 | pubmed:meshHeading | pubmed-meshheading:12682259... | lld:pubmed |
| pubmed-article:12682259 | pubmed:meshHeading | pubmed-meshheading:12682259... | lld:pubmed |
| pubmed-article:12682259 | pubmed:meshHeading | pubmed-meshheading:12682259... | lld:pubmed |
| pubmed-article:12682259 | pubmed:meshHeading | pubmed-meshheading:12682259... | lld:pubmed |
| pubmed-article:12682259 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12682259 | pubmed:articleTitle | TCR V beta 8+ T cells prevent development of toxoplasmic encephalitis in BALB/c mice genetically resistant to the disease. | lld:pubmed |
| pubmed-article:12682259 | pubmed:affiliation | Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. | lld:pubmed |
| pubmed-article:12682259 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12682259 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:12682259 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12682259 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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