Source:http://linkedlifedata.com/resource/pubmed/id/12682259
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
2003-4-8
|
| pubmed:abstractText |
BALB/c are genetically resistant to development of toxoplasmic encephalitis (TE) when infected with Toxoplasma gondii, whereas CBA/Ca mice are susceptible. We compared TCR Vbeta chain usage in lymphocytes infiltrated into brains between these animals following infection. TCR Vbeta8(+) cells were the most frequent T cell population in brains of infected, resistant BALB/c mice, whereas TCR Vbeta6(+) T cells were more prevalent than Vbeta8(+) T cells in brains of infected, susceptible CBA/Ca mice. Adoptive transfer of Vbeta8(+) immune T cells, obtained from infected BALB/c mice, prevented development of TE and mortality in infected athymic nude mice that lack T cells. In contrast, adoptive transfer of Vbeta6(+) immune T cells did not prevent development of TE or mortality in the nude mice. The protective activity of Vbeta8(+) immune T cells was greater than that of the total Vbeta8(-) population. In addition, Vbeta8(+) immune T cells produced markedly greater amounts of IFN-gamma than did the Vbeta8(-) population after stimulation with tachyzoite lysate Ags in vitro. Thus, Vbeta8(+) T cells appear to play a crucial role in the genetic resistance of BALB/c mice against development of TE.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0022-1767
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
170
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
4254-9
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:12682259-Adoptive Transfer,
pubmed-meshheading:12682259-Animals,
pubmed-meshheading:12682259-Biological Markers,
pubmed-meshheading:12682259-Brain,
pubmed-meshheading:12682259-Cell Movement,
pubmed-meshheading:12682259-Encephalitis,
pubmed-meshheading:12682259-Female,
pubmed-meshheading:12682259-Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor,
pubmed-meshheading:12682259-Gene Rearrangement, beta-Chain T-Cell Antigen Receptor,
pubmed-meshheading:12682259-Genetic Predisposition to Disease,
pubmed-meshheading:12682259-Immunity, Innate,
pubmed-meshheading:12682259-Interferon-gamma,
pubmed-meshheading:12682259-Killer Cells, Natural,
pubmed-meshheading:12682259-Lymphocyte Count,
pubmed-meshheading:12682259-Mice,
pubmed-meshheading:12682259-Mice, Inbred BALB C,
pubmed-meshheading:12682259-Mice, Inbred CBA,
pubmed-meshheading:12682259-Mice, Nude,
pubmed-meshheading:12682259-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:12682259-T-Lymphocyte Subsets,
pubmed-meshheading:12682259-Toxoplasma,
pubmed-meshheading:12682259-Toxoplasmosis, Animal,
pubmed-meshheading:12682259-Toxoplasmosis, Cerebral
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
TCR V beta 8+ T cells prevent development of toxoplasmic encephalitis in BALB/c mice genetically resistant to the disease.
|
| pubmed:affiliation |
Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|