Source:http://linkedlifedata.com/resource/pubmed/id/12660488
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2003-3-27
|
| pubmed:abstractText |
In an association study, the relationship between the insertion/deletion (I/D) plasminogen activator inhibitor 1 (PAI-1) gene polymorphism or the I/D angiotensin 1-converting enzyme (ACE) gene polymorphism and the development of diabetic retinopathy in patients with type 2 diabetes was investigated. One hundred and twenty-four subjects with type 2 diabetes and diabetic retinopathy were compared to 80 diabetic subjects without retinopathy with diabetes of a duration of more than 10 years. The PAI-1 gene distribution and ACE gene distribution in patients with diabetic retinopathy (4G4G 31.4%, 4G5G 46.8%, 5G5G 21.8%; DD 26.6%, ID 50.8%, II 22.6%) were not significantly different from those of diabetic subjects without retinopathy (4G4G 31.3%, 4G5G 50%, 5G5G 18.7%; DD 31.3%, ID 40%, II 28.7%). Neither the 4G/5G PAI-1 gene polymorphism nor the I/D ACE gene polymorphism contributed to the genetic susceptibility to diabetic retinopathy, either non-proliferative, proliferative or severe proliferative diabetic retinopathy, i.e. visual acuity of 0.1 or less in the better eye, in a group of Caucasian subjects with type 2 diabetes.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0030-3755
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2003 S. Karger AG, Basel
|
| pubmed:issnType |
Print
|
| pubmed:volume |
217
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
219-24
|
| pubmed:dateRevised |
2007-9-17
|
| pubmed:meshHeading |
pubmed-meshheading:12660488-Aged,
pubmed-meshheading:12660488-Diabetes Mellitus, Type 2,
pubmed-meshheading:12660488-Diabetic Retinopathy,
pubmed-meshheading:12660488-European Continental Ancestry Group,
pubmed-meshheading:12660488-Female,
pubmed-meshheading:12660488-Gene Deletion,
pubmed-meshheading:12660488-Gene Frequency,
pubmed-meshheading:12660488-Genotype,
pubmed-meshheading:12660488-Glycine,
pubmed-meshheading:12660488-Humans,
pubmed-meshheading:12660488-Male,
pubmed-meshheading:12660488-Middle Aged,
pubmed-meshheading:12660488-Mutagenesis, Insertional,
pubmed-meshheading:12660488-Odds Ratio,
pubmed-meshheading:12660488-Peptidyl-Dipeptidase A,
pubmed-meshheading:12660488-Plasminogen Activator Inhibitor 1,
pubmed-meshheading:12660488-Polymerase Chain Reaction,
pubmed-meshheading:12660488-Polymorphism, Single-Stranded Conformational,
pubmed-meshheading:12660488-Risk
|
| pubmed:articleTitle |
Insertion/deletion plasminogen activator inhibitor 1 and insertion/deletion angiotensin-converting enzyme gene polymorphisms in diabetic retinopathy in type 2 diabetes.
|
| pubmed:affiliation |
Eye Clinic, University Medical Centre Ljubljana, Ljubljana, Slovenia.
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|