|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0040300,
umls-concept:C0078058,
umls-concept:C0205314,
umls-concept:C0542341,
umls-concept:C0679622,
umls-concept:C1167622,
umls-concept:C1256770,
umls-concept:C1336630,
umls-concept:C1510884,
umls-concept:C1706968,
umls-concept:C1999216
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2003-4-3
|
|
pubmed:abstractText |
Tissue inhibitor of metalloproteinases-3 (TIMP3) is one of four members of a family of proteins that were originally classified according to their ability to inhibit matrix metalloproteinases (MMP). TIMP3, which encodes a potent angiogenesis inhibitor, is mutated in Sorsby fundus dystrophy, a macular degenerative disease with submacular choroidal neovascularization. In this study we demonstrate the ability of TIMP3 to inhibit vascular endothelial factor (VEGF)-mediated angiogenesis and identify the potential mechanism by which this occurs: TIMP3 blocks the binding of VEGF to VEGF receptor-2 and inhibits downstream signaling and angiogenesis. This property seems to be independent of its MMP-inhibitory activity, indicating a new function for this molecule.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Endothelial Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphokines,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropilins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Vascular Endothelial...,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/TIMP3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tissue Inhibitor of...,
http://linkedlifedata.com/resource/pubmed/chemical/Tissue Inhibitor of...,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factors
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
1078-8956
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
9
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
407-15
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:12652295-Cell Division,
pubmed-meshheading:12652295-Cell Line,
pubmed-meshheading:12652295-Endothelial Growth Factors,
pubmed-meshheading:12652295-Endothelium,
pubmed-meshheading:12652295-Humans,
pubmed-meshheading:12652295-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:12652295-Lymphokines,
pubmed-meshheading:12652295-Neovascularization, Pathologic,
pubmed-meshheading:12652295-Neuropilins,
pubmed-meshheading:12652295-Phosphorylation,
pubmed-meshheading:12652295-Receptors, Vascular Endothelial Growth Factor,
pubmed-meshheading:12652295-Recombinant Proteins,
pubmed-meshheading:12652295-Tissue Inhibitor of Metalloproteinase-3,
pubmed-meshheading:12652295-Tissue Inhibitor of Metalloproteinases,
pubmed-meshheading:12652295-Vascular Endothelial Growth Factor A,
pubmed-meshheading:12652295-Vascular Endothelial Growth Factors
|
|
pubmed:year |
2003
|
|
pubmed:articleTitle |
A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2.
|
|
pubmed:affiliation |
Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
