Source:http://linkedlifedata.com/resource/pubmed/id/12648074
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2003-3-21
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| pubmed:abstractText |
We have published previously a prototype of a decision model for anaemic patients with myelodysplastic syndromes (MDS), in which transfusion need and serum erythropoietin (S-Epo) were used to define three groups with different probabilities of erythroid response to treatment with granulocyte colony-stimulating factor (G-CSF) + Epo. S-Epo </= 500 U/l and a transfusion need of < 2 units/month predicted a high probability of response to treatment, S-Epo > 500 U/l and >/= 2 units/month for a poor response, whereas the presence of only one negative prognostic marker predicted an intermediate response. A total of 53 patients from a prospective study were included in our evaluation sample. Patients with good or intermediate probability of response were treated with G-CSF + Epo. The overall response rate was 42% with 28.3% achieving a complete and 13.2% a partial response to treatment. The response rates were 61% and 14% in the good and intermediate predictive groups respectively. The model retained a significant predictive value in the evaluation sample (P < 0.001). Median duration of response was 23 months. Scores for global health and quality of life (QOL) were significantly lower in MDS patients than in a reference population, and fatigue and dyspnoea was significantly more prominent. Global QOL improved in patients responding to treatment (P = 0.01). The validated decision model defined a subgroup of patients with a response rate of 61% (95% confidence interval 48-74%) to treatment with G-CSF + Epo. The majority of these patients have shown complete and durable responses.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
0007-1048
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| pubmed:author |
pubmed-author:AhlgrenTomasT,
pubmed-author:DahlInger Marie SIM,
pubmed-author:DybedalIngunnI,
pubmed-author:GrimforsGunnarG,
pubmed-author:GulbrandsenNinaN,
pubmed-author:Hellström-LindbergEvaE,
pubmed-author:Hesse-SundinEvaE,
pubmed-author:HjorthMartinM,
pubmed-author:Kanter-LewensohnLenaL,
pubmed-author:LöfvenbergEvaE,
pubmed-author:LindbergGregerG,
pubmed-author:LinderOlleO,
pubmed-author:LuthmanMichaelaM,
pubmed-author:ObergGunnarG,
pubmed-author:Porwit-MacDonaldAnjaA,
pubmed-author:RådlundAndersA,
pubmed-author:SamuelssonJanJ,
pubmed-author:Scandinavian MDS Group,
pubmed-author:TangenJon MagnusJM,
pubmed-author:WinquistIngemarI,
pubmed-author:WisloffFinnF
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| pubmed:issnType |
Print
|
| pubmed:volume |
120
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1037-46
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:12648074-Aged,
pubmed-meshheading:12648074-Anemia,
pubmed-meshheading:12648074-Anemia, Refractory,
pubmed-meshheading:12648074-Anemia, Refractory, with Excess of Blasts,
pubmed-meshheading:12648074-Anemia, Sideroblastic,
pubmed-meshheading:12648074-Blood Transfusion,
pubmed-meshheading:12648074-Decision Support Techniques,
pubmed-meshheading:12648074-Erythropoietin,
pubmed-meshheading:12648074-Female,
pubmed-meshheading:12648074-Granulocyte Colony-Stimulating Factor,
pubmed-meshheading:12648074-Humans,
pubmed-meshheading:12648074-Male,
pubmed-meshheading:12648074-Middle Aged,
pubmed-meshheading:12648074-Myelodysplastic Syndromes,
pubmed-meshheading:12648074-Prognosis,
pubmed-meshheading:12648074-Prospective Studies,
pubmed-meshheading:12648074-Quality of Life,
pubmed-meshheading:12648074-Treatment Outcome
|
| pubmed:year |
2003
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| pubmed:articleTitle |
A validated decision model for treating the anaemia of myelodysplastic syndromes with erythropoietin + granulocyte colony-stimulating factor: significant effects on quality of life.
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| pubmed:affiliation |
Department of Medicine, Karolinska Institutet at Huddinge University Hospital, Stockholm, Sweden. Eva.Hellstrom-Lindberg@medhs.ki.se
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study
|