Linked Life Data

12642500

Source:http://linkedlifedata.com/resource/pubmed/id/12642500

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2003-3-18
pubmed:abstractText
Su(H)/CBF1 is a key component of the evolutionary conserved Notch signalling pathway. It is a transcription factor that acts as a repressor in the absence of the Notch signal. If Notch signalling is activated, it associates with the released intracellular domain of the Notch receptor and acts as an activator of transcription. During the development of the mechanosensory bristles of Drosophila, a selection process called lateral inhibition assures that only a few cells are selected out of a group to become sensory organ precursors (SOP). During this process, the SOP cell is thought to suppress the same fate in its surrounding neighbours via the activation of the Notch/Su(H) pathway in these cells. We show that, although Su(H) is required to prevent the SOP fate during lateral inhibition, it is also required to promote the further development of the SOP once it is selected. Importantly, in this situation Su(H) appears to act independently of the Notch signalling pathway. We find that loss of Su(H) function leads to an arrest of SOP development because of the loss of sens expression in the SOP. Our results suggest that Su(H) acts as a repressor that suppresses the activity of one or more negative regulator(s) of sens expression. We show that this repressor activity is encoded by one or several genes of the E(spl)-complex. Our results further suggest that the position of the SOP in a proneural cluster is determined by very precise positional cues, which render the SOP insensitive to Dl.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0950-1991
pubmed:author
pubmed:issnType
Print
pubmed:volume
130
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1973-88
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
A Notch-independent function of Suppressor of Hairless during the development of the bristle sensory organ precursor cell of Drosophila.
pubmed:affiliation
Institute für Genetik, Universitaet zu Koeln, Weyertal 121, 50931 Koeln, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't