| pubmed-article:12619901 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12619901 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:12619901 | lifeskim:mentions | umls-concept:C0034392 | lld:lifeskim |
| pubmed-article:12619901 | lifeskim:mentions | umls-concept:C0752312 | lld:lifeskim |
| pubmed-article:12619901 | lifeskim:mentions | umls-concept:C1327413 | lld:lifeskim |
| pubmed-article:12619901 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:12619901 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:12619901 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:12619901 | pubmed:dateCreated | 2003-3-6 | lld:pubmed |
| pubmed-article:12619901 | pubmed:abstractText | Quercetin is a flavonoid molecule ubiquitous in nature and functions as an anti-oxidant and anti-inflammatory agent with little toxicity in vivo and in vitro. Dose- and time-dependent effect of quercetin has been investigated on proinflammatory cytokine expression and NO production, focusing on its effects on the MAP kinases and the NF-kappaB signal transduction pathways in LPS-stimulated RAW 264.7 cells by using RT-PCR and immunoblotting. Quercetin strongly reduced activation of phosphorylated ERK kinase and p38 MAP kinase but not JNK MAP kinase by LPS treatment. In addition, quercetin treatment inhibited NF-kappaB activation through stabilization of the NF-kappaB/IkappaB complex and IkappaB degradation and proinflammatory cytokines and NO/iNOS expression. Quercetin may exert its anti-inflammatory and immunomodulatory properties in the effect molecules such as proinflammatory cytokines and NO/iNOS by suppressing the activation of ERK and p38 MAP kinase, and NF-kappaB/IkappaB signal transduction pathways. | lld:pubmed |
| pubmed-article:12619901 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12619901 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12619901 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12619901 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12619901 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12619901 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12619901 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12619901 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:12619901 | pubmed:issn | 0300-8177 | lld:pubmed |
| pubmed-article:12619901 | pubmed:author | pubmed-author:BokSong-HaeSH | lld:pubmed |
| pubmed-article:12619901 | pubmed:author | pubmed-author:JeongTae-Sook... | lld:pubmed |
| pubmed-article:12619901 | pubmed:author | pubmed-author:JeongWon-IlWI | lld:pubmed |
| pubmed-article:12619901 | pubmed:author | pubmed-author:LeeCha-SooCS | lld:pubmed |
| pubmed-article:12619901 | pubmed:author | pubmed-author:ParkSang-Joon... | lld:pubmed |
| pubmed-article:12619901 | pubmed:author | pubmed-author:JeongKyu-Shik... | lld:pubmed |
| pubmed-article:12619901 | pubmed:author | pubmed-author:KwonMyung-JaM... | lld:pubmed |
| pubmed-article:12619901 | pubmed:author | pubmed-author:RyuSi-YunSY | lld:pubmed |
| pubmed-article:12619901 | pubmed:author | pubmed-author:ChoSung-YeonS... | lld:pubmed |
| pubmed-article:12619901 | pubmed:author | pubmed-author:ChoiWoo-Young... | lld:pubmed |
| pubmed-article:12619901 | pubmed:author | pubmed-author:DoSun-HeeSH | lld:pubmed |
| pubmed-article:12619901 | pubmed:author | pubmed-author:SongJae-ChanJ... | lld:pubmed |
| pubmed-article:12619901 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12619901 | pubmed:volume | 243 | lld:pubmed |
| pubmed-article:12619901 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12619901 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12619901 | pubmed:pagination | 153-60 | lld:pubmed |
| pubmed-article:12619901 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:12619901 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12619901 | pubmed:articleTitle | Quercetin suppresses proinflammatory cytokines production through MAP kinases andNF-kappaB pathway in lipopolysaccharide-stimulated macrophage. | lld:pubmed |
| pubmed-article:12619901 | pubmed:affiliation | Korea Research Institute of Bioscience and Biotechnology, Yusung, Taejon City, South Korea. | lld:pubmed |
| pubmed-article:12619901 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12619901 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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