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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2003-3-6
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pubmed:abstractText |
Quercetin is a flavonoid molecule ubiquitous in nature and functions as an anti-oxidant and anti-inflammatory agent with little toxicity in vivo and in vitro. Dose- and time-dependent effect of quercetin has been investigated on proinflammatory cytokine expression and NO production, focusing on its effects on the MAP kinases and the NF-kappaB signal transduction pathways in LPS-stimulated RAW 264.7 cells by using RT-PCR and immunoblotting. Quercetin strongly reduced activation of phosphorylated ERK kinase and p38 MAP kinase but not JNK MAP kinase by LPS treatment. In addition, quercetin treatment inhibited NF-kappaB activation through stabilization of the NF-kappaB/IkappaB complex and IkappaB degradation and proinflammatory cytokines and NO/iNOS expression. Quercetin may exert its anti-inflammatory and immunomodulatory properties in the effect molecules such as proinflammatory cytokines and NO/iNOS by suppressing the activation of ERK and p38 MAP kinase, and NF-kappaB/IkappaB signal transduction pathways.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/I-kappa B Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappaB inhibitor alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Quercetin,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/p38 Mitogen-Activated Protein...
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0300-8177
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pubmed:author |
pubmed-author:BokSong-HaeSH,
pubmed-author:ChoSung-YeonSY,
pubmed-author:ChoiWoo-YoungWY,
pubmed-author:DoSun-HeeSH,
pubmed-author:JeongKyu-ShikKS,
pubmed-author:JeongTae-SookTS,
pubmed-author:JeongWon-IlWI,
pubmed-author:KwonMyung-JaMJ,
pubmed-author:LeeCha-SooCS,
pubmed-author:ParkSang-JoonSJ,
pubmed-author:RyuSi-YunSY,
pubmed-author:SongJae-ChanJC
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pubmed:issnType |
Print
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pubmed:volume |
243
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
153-60
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12619901-Animals,
pubmed-meshheading:12619901-Cell Line,
pubmed-meshheading:12619901-Cytokines,
pubmed-meshheading:12619901-Dose-Response Relationship, Drug,
pubmed-meshheading:12619901-Enzyme Activation,
pubmed-meshheading:12619901-I-kappa B Proteins,
pubmed-meshheading:12619901-Immunoblotting,
pubmed-meshheading:12619901-Lipopolysaccharides,
pubmed-meshheading:12619901-MAP Kinase Signaling System,
pubmed-meshheading:12619901-Macrophages,
pubmed-meshheading:12619901-Mice,
pubmed-meshheading:12619901-Mitogen-Activated Protein Kinases,
pubmed-meshheading:12619901-NF-kappa B,
pubmed-meshheading:12619901-Nitric Oxide,
pubmed-meshheading:12619901-Quercetin,
pubmed-meshheading:12619901-RNA, Messenger,
pubmed-meshheading:12619901-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:12619901-Signal Transduction,
pubmed-meshheading:12619901-Time Factors,
pubmed-meshheading:12619901-p38 Mitogen-Activated Protein Kinases
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pubmed:year |
2003
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pubmed:articleTitle |
Quercetin suppresses proinflammatory cytokines production through MAP kinases andNF-kappaB pathway in lipopolysaccharide-stimulated macrophage.
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pubmed:affiliation |
Korea Research Institute of Bioscience and Biotechnology, Yusung, Taejon City, South Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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