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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2003-3-5
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pubmed:abstractText |
We evaluated by immunocytochemistry cellular localization and time-dependent expression of tumor necrosis factor a (TNF-alpha) and its receptors p55 (TNF-RI) and p75 (TNF-R2) in human ischemic brains. We observed them in microglia, neurons, astrocytes, macrophages and blood vessels. Since TNF-alpha expression was very intense and prolonged in microglia, it probably constitutes the main cellular source of the cytokine following cerebral ischemia in humans. Constitutive expression of TNF-alpha receptors was observed in neurons and blood vessels while in other cells it was induced by ischemia. In macrophages, dominant immunolabeling for TNF-R2 was seen. In other cells, immunoreactions for both types of TNF-alpha receptors were similar but the pattern of immunostaining was different: homogenous for TNF-R1 and granular for TNF-R2. Beneficial and detrimental role of TNF-alpha in cerebral ischemia and supposed mechanisms of action are discussed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0722-5091
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
35-40
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:12617192-Aged,
pubmed-meshheading:12617192-Aged, 80 and over,
pubmed-meshheading:12617192-Antigens, CD,
pubmed-meshheading:12617192-Antineoplastic Agents,
pubmed-meshheading:12617192-Brain,
pubmed-meshheading:12617192-Brain Ischemia,
pubmed-meshheading:12617192-Female,
pubmed-meshheading:12617192-Humans,
pubmed-meshheading:12617192-Macrophages,
pubmed-meshheading:12617192-Male,
pubmed-meshheading:12617192-Middle Aged,
pubmed-meshheading:12617192-Neuroglia,
pubmed-meshheading:12617192-Neurons,
pubmed-meshheading:12617192-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:12617192-Receptors, Tumor Necrosis Factor, Type I,
pubmed-meshheading:12617192-Receptors, Tumor Necrosis Factor, Type II,
pubmed-meshheading:12617192-Stroke,
pubmed-meshheading:12617192-Time Factors,
pubmed-meshheading:12617192-Tumor Necrosis Factor-alpha
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pubmed:articleTitle |
Cellular expression of tumor necrosis factor a and its receptors in human ischemic stroke.
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pubmed:affiliation |
Department of Neurology, Medical University of Warsaw, Poland. ddziewul@amwaw.edu.pl
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pubmed:publicationType |
Journal Article
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