rdf:type |
|
lifeskim:mentions |
umls-concept:C0023434,
umls-concept:C0030685,
umls-concept:C0041904,
umls-concept:C0162638,
umls-concept:C0391871,
umls-concept:C0596138,
umls-concept:C0680255,
umls-concept:C1283071,
umls-concept:C1456820,
umls-concept:C1539081,
umls-concept:C1963578,
umls-concept:C2349975
|
pubmed:issue |
2
|
pubmed:dateCreated |
2003-2-26
|
pubmed:abstractText |
In chronic lymphocytic leukemia (CLL) B-cells are refractory to activation signals and to apoptosis. CD40 triggering, however, rescues CLL B-cells from their anergic state and upregulates the FAS receptor. We therefore studied whether CD40 triggering enhances CLL B-cell sensitivity to fludarabine, and receptors or cytokines potentially involved in apoptosis.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
0390-6078
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
88
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
148-58
|
pubmed:dateRevised |
2008-11-21
|
pubmed:meshHeading |
pubmed-meshheading:12604404-Aged,
pubmed-meshheading:12604404-Aged, 80 and over,
pubmed-meshheading:12604404-Antigens, CD40,
pubmed-meshheading:12604404-Apoptosis,
pubmed-meshheading:12604404-Autocrine Communication,
pubmed-meshheading:12604404-B-Lymphocytes,
pubmed-meshheading:12604404-CD40 Ligand,
pubmed-meshheading:12604404-Female,
pubmed-meshheading:12604404-Humans,
pubmed-meshheading:12604404-Interferon-gamma,
pubmed-meshheading:12604404-Leukemia, Lymphocytic, Chronic, B-Cell,
pubmed-meshheading:12604404-Male,
pubmed-meshheading:12604404-Middle Aged,
pubmed-meshheading:12604404-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:12604404-Tumor Necrosis Factor-alpha,
pubmed-meshheading:12604404-Up-Regulation,
pubmed-meshheading:12604404-Vidarabine
|
pubmed:year |
2003
|
pubmed:articleTitle |
CD40 triggering enhances fludarabine-induced apoptosis of chronic lymphocytic leukemia B-cells through autocrine release of tumor necrosis factor-alpha and interferon-gama and tumor necrosis factor receptor-I-II upregulation.
|
pubmed:affiliation |
Department of Internal Medicine, University of Genoa, Italy. detotero@yahoo.com
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|