Source:http://linkedlifedata.com/resource/pubmed/id/12601528
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2003-2-25
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pubmed:abstractText |
Aging-related loss of muscle function is a predictor of mortality and a surrogate parameter of the aging process. Its consequences include a high risk for falls, hip fractures, and loss of autonomy. Aging is associated with changes in the oxidant/antioxidant balance including a decrease in plasma thiol (cysteine) concentration. To assess the importance of cysteine, we determined in a double-blind study the effects of N-acetylcysteine on the functional capacity of frail geriatric patients and their response to physical exercise. The subjects on placebo showed only a relatively weak response, and 31% showed even a decrease in more than one parameter during the observation period. Low plasma arginine levels were correlated with a weak overall performance before exercise and a poor response to exercise. N-Acetylcysteine strongly enhanced the increase in knee extensor strength and significantly increased the sum of all strength parameters if adjusted for baseline arginine level as a confounding parameter. N-acetylcysteine had no significant effect on growth hormone and IGF-1 levels but caused a significant decrease in plasma TNF-alpha. These findings may provide a basis for therapeutic intervention and suggest that the loss of function involves limitations in cysteine and one or more other amino acids which may compromise muscular protein synthesis.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0946-2716
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
118-25
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pubmed:dateRevised |
2011-7-8
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pubmed:meshHeading |
pubmed-meshheading:12601528-Acetylcysteine,
pubmed-meshheading:12601528-Aged,
pubmed-meshheading:12601528-Antioxidants,
pubmed-meshheading:12601528-Cognition,
pubmed-meshheading:12601528-Exercise,
pubmed-meshheading:12601528-Humans,
pubmed-meshheading:12601528-Muscles,
pubmed-meshheading:12601528-Tumor Necrosis Factor-alpha
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pubmed:year |
2003
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pubmed:articleTitle |
Improvement in muscular performance and decrease in tumor necrosis factor level in old age after antioxidant treatment.
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pubmed:affiliation |
Bethanien Krankenhaus, Geriatrisches Zentrum der Universität Heidelberg, Rohrbacher Strasse 149, 69126, Heidelberg, Germany.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
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