|
rdf:type |
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lifeskim:mentions |
umls-concept:C0006104,
umls-concept:C0021308,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0026336,
umls-concept:C0032143,
umls-concept:C0034693,
umls-concept:C0038454,
umls-concept:C0080093,
umls-concept:C0184511,
umls-concept:C0205195,
umls-concept:C0205494,
umls-concept:C0392756,
umls-concept:C0449468,
umls-concept:C1274040,
umls-concept:C1415300,
umls-concept:C1711351
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pubmed:issue |
2
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|
pubmed:dateCreated |
2003-2-20
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|
pubmed:abstractText |
A novel postsynaptic antagonist of N-methyl-D-aspartate (NMDA) receptors, CP-101,606-27 may attenuate the effects of focal ischemia. In current experiments, the authors investigated its neuroprotective effect alone and in combination with recombinant tissue plasminogen activator (rt-PA) in thromboembolic focal cerebral ischemia in rats.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-3085
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
98
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
397-403
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:12593629-Animals,
pubmed-meshheading:12593629-Brain Infarction,
pubmed-meshheading:12593629-Disease Models, Animal,
pubmed-meshheading:12593629-Drug Therapy, Combination,
pubmed-meshheading:12593629-Male,
pubmed-meshheading:12593629-Nervous System Diseases,
pubmed-meshheading:12593629-Neuroprotective Agents,
pubmed-meshheading:12593629-Piperidines,
pubmed-meshheading:12593629-Plasminogen Activators,
pubmed-meshheading:12593629-Rats,
pubmed-meshheading:12593629-Rats, Wistar,
pubmed-meshheading:12593629-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:12593629-Recombinant Proteins,
pubmed-meshheading:12593629-Severity of Illness Index,
pubmed-meshheading:12593629-Stroke,
pubmed-meshheading:12593629-Thromboembolism,
pubmed-meshheading:12593629-Tissue Plasminogen Activator
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pubmed:year |
2003
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pubmed:articleTitle |
Reduced brain infarct volume and improved neurological outcome by inhibition of the NR2B subunit of NMDA receptors by using CP101,606-27 alone and in combination with rt-PA in a thromboembolic stroke model in rats.
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pubmed:affiliation |
Acute Stroke Program, Neurology Division, University of Alberta Hospital, Edmonton, Alberta, Canada.
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pubmed:publicationType |
Journal Article
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