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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2003-2-10
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pubmed:abstractText |
Mice lacking a functional bombesin receptor subtype-3 (BRS-3) develop mild obesity. However, the origin of obesity in BRS-3 knockout (KO) mice remains unclear. We used a strain-crossing strategy to investigate the physiological role of the BRS-3 pathway. We crossed female heterozygous BRS-3 KO mice (X-/X) and male KK-Ay mice (Ay/+) to obtain BRS-3 KO/KK-Ay hybrid animals. In X-/Y:Ay/+ mice, plasma insulin concentrations were significantly higher, and on the oral glucose tolerance test, the additional secretion of insulin was impaired compared to other genotypes. Our results indicate that the BRS-3 pathway contributes to the regulation of plasma insulin concentrations.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0196-9781
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2002 Elsevier Science Inc.
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pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
83-90
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:12576088-Animals,
pubmed-meshheading:12576088-Appetite Depressants,
pubmed-meshheading:12576088-Cyclobutanes,
pubmed-meshheading:12576088-Drinking Behavior,
pubmed-meshheading:12576088-Feeding Behavior,
pubmed-meshheading:12576088-Female,
pubmed-meshheading:12576088-Genotype,
pubmed-meshheading:12576088-Glucose Tolerance Test,
pubmed-meshheading:12576088-Insulin,
pubmed-meshheading:12576088-Male,
pubmed-meshheading:12576088-Mice,
pubmed-meshheading:12576088-Receptors, Bombesin
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pubmed:year |
2003
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pubmed:articleTitle |
Bombesin receptor subtype-3 modulates plasma insulin concentration.
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pubmed:affiliation |
Department of Pharmaceuticals Research Laboratory, Mitsubishi Pharma Corporation, 1000 Kamoshida-cho, Aoba-ku, Yokohama-City, Kanagawa 227-0033, Japan. Matsumoto.Kouji@mk.m-pharma.co.jp
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pubmed:publicationType |
Journal Article
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