Source:http://linkedlifedata.com/resource/pubmed/id/12574320
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2003-2-7
|
| pubmed:abstractText |
Perforin mediates target cell apoptosis by CTLs and NK cells. Although perforin expression correlates strongly with acute allograft rejection, perforin-deficient mice reject allografts with the same kinetics as wild-type recipients. In this study, we tested the hypothesis that while perforin is dispensable for acute rejection, it is essential for down-regulating the alloimmune response by inducing the apoptosis of host immune cells. Using a skin transplantation model, we found that perforin-deficient mice are resistant to the induction of allograft acceptance by agents that block T cell costimulation. Failure to induce allograft acceptance in these mice was observed irrespective of whether the alloimmune response was CD4 or CD8 T cell-mediated and could be attributed to defective apoptosis of activated CD4 and CD8 T cells. In contrast, perforin did not influence T cell proliferation. Therefore, perforin is an essential immunoregulatory molecule that may be required for the induction of transplantation tolerance.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0022-1767
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
170
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1611-4
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:12574320-Animals,
pubmed-meshheading:12574320-Apoptosis,
pubmed-meshheading:12574320-CD4-Positive T-Lymphocytes,
pubmed-meshheading:12574320-CD8-Positive T-Lymphocytes,
pubmed-meshheading:12574320-Cell Division,
pubmed-meshheading:12574320-Down-Regulation,
pubmed-meshheading:12574320-Genes, MHC Class I,
pubmed-meshheading:12574320-Genes, MHC Class II,
pubmed-meshheading:12574320-Graft Survival,
pubmed-meshheading:12574320-Histocompatibility Testing,
pubmed-meshheading:12574320-Immunity, Cellular,
pubmed-meshheading:12574320-Lymphocyte Activation,
pubmed-meshheading:12574320-Male,
pubmed-meshheading:12574320-Membrane Glycoproteins,
pubmed-meshheading:12574320-Mice,
pubmed-meshheading:12574320-Mice, Inbred BALB C,
pubmed-meshheading:12574320-Mice, Inbred C57BL,
pubmed-meshheading:12574320-Mice, Knockout,
pubmed-meshheading:12574320-Perforin,
pubmed-meshheading:12574320-Pore Forming Cytotoxic Proteins,
pubmed-meshheading:12574320-Skin Transplantation,
pubmed-meshheading:12574320-Time Factors,
pubmed-meshheading:12574320-Transplantation, Homologous
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
Cutting edge: perforin down-regulates CD4 and CD8 T cell-mediated immune responses to a transplanted organ.
|
| pubmed:affiliation |
Section of Nephrology, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|