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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2003-2-3
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pubmed:abstractText |
Optimal T-cell activation requires both an antigen-specific and a costimulatory signal. The outcome of T-cell activation can be influenced by the nature of the costimulatory signal the T cell receives. We recently demonstrated the ability of stimulation through intercellular adhesion molecule-1 (ICAM-1), resident on the T-cell surface, to provide a second signal for T-cell activation, and have extended that work here to begin an examination of the functional outcome of this set of signals. Costimulation through ICAM-1 resulted in a greater percentage of cells having undergone more than three divisions when compared to costimulation through leucocyte function-associated antigen-1 (LFA-1). Costimulation through ICAM-1 also had an effect similar to costimulation through CD28 in its ability to down-regulate the cyclin dependent kinase inhibitor p27kip1. Costimulation through ICAM-1 provided greater protection from apoptosis than costimulation through LFA-1, especially in cells having divided more than three times. This was supported by the ability of costimulation through ICAM-1 to up-regulate the anti-apoptotic protein Bcl-2. Finally, costimulation through ICAM-1 or CD28 produced a greater number of T cells with a memory phenotype than costimulation through LFA-1.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562323-10227991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562323-10507489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562323-10614768,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562323-10924857,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562323-11120881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562323-11165519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562323-11175858,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562323-11290331,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562323-11441079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562323-11461120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562323-11721060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562323-11825560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562323-11884439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562323-12023348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562323-2113314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562323-7499827,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562323-7539104,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562323-7576051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562323-7621080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562323-7990932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562323-8405057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562323-8717514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562323-9034725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562323-9203422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562323-9529145,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562323-9531282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12562323-9820482
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
108
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
152-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12562323-Antigens, CD11,
pubmed-meshheading:12562323-Apoptosis,
pubmed-meshheading:12562323-Cell Division,
pubmed-meshheading:12562323-Cells, Cultured,
pubmed-meshheading:12562323-Humans,
pubmed-meshheading:12562323-Intercellular Adhesion Molecule-1,
pubmed-meshheading:12562323-Lymphocyte Activation,
pubmed-meshheading:12562323-Lymphocyte Function-Associated Antigen-1,
pubmed-meshheading:12562323-T-Lymphocyte Subsets,
pubmed-meshheading:12562323-T-Lymphocytes
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pubmed:year |
2003
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pubmed:articleTitle |
The outcome of T-cell costimulation through intercellular adhesion molecule-1 differs from costimulation through leucocyte function-associated antigen-1.
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pubmed:affiliation |
Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66045, USA.
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pubmed:publicationType |
Journal Article
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