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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2003-1-28
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pubmed:abstractText |
There is an ongoing debate as to whether the gastrointestinal safety of COX-2 inhibition compared with nonsteroidal antiinflammatory drugs (NSAIDs) may come at the cost of increased cardiovascular events. In view of the large number of patients at cardiovascular risk requiring chronic analgesic therapy with COX-2 inhibitors for arthritic and other inflammatory conditions, the effects of selective COX-2 inhibition on clinically useful surrogates for cardiovascular disease, particularly endothelial function, need to be determined.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/C-Reactive Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2 Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PTGS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides,
http://linkedlifedata.com/resource/pubmed/chemical/celecoxib,
http://linkedlifedata.com/resource/pubmed/chemical/oxidized low density lipoprotein
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1524-4539
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pubmed:author |
pubmed-author:BéchirMarkusM,
pubmed-author:ChenevardRémyR,
pubmed-author:EnseleitFrankF,
pubmed-author:GayRenate ERE,
pubmed-author:GaySteffenS,
pubmed-author:HürlimannDavidD,
pubmed-author:HermannMatthiasM,
pubmed-author:LüscherThomas FTF,
pubmed-author:MichelBeatB,
pubmed-author:NeidhartMichelM,
pubmed-author:NollGeorgG,
pubmed-author:RiesenWalterW,
pubmed-author:RuschitzkaFrankF,
pubmed-author:SpiekerLukasL
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pubmed:issnType |
Electronic
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pubmed:day |
28
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pubmed:volume |
107
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
405-9
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:12551863-Aged,
pubmed-meshheading:12551863-Biological Markers,
pubmed-meshheading:12551863-C-Reactive Protein,
pubmed-meshheading:12551863-Coronary Artery Disease,
pubmed-meshheading:12551863-Cross-Over Studies,
pubmed-meshheading:12551863-Cyclooxygenase 2,
pubmed-meshheading:12551863-Cyclooxygenase 2 Inhibitors,
pubmed-meshheading:12551863-Cyclooxygenase Inhibitors,
pubmed-meshheading:12551863-Double-Blind Method,
pubmed-meshheading:12551863-Endothelium, Vascular,
pubmed-meshheading:12551863-Humans,
pubmed-meshheading:12551863-Isoenzymes,
pubmed-meshheading:12551863-Lipoproteins, LDL,
pubmed-meshheading:12551863-Male,
pubmed-meshheading:12551863-Membrane Proteins,
pubmed-meshheading:12551863-Middle Aged,
pubmed-meshheading:12551863-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:12551863-Pyrazoles,
pubmed-meshheading:12551863-Sulfonamides,
pubmed-meshheading:12551863-Vasodilation
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pubmed:year |
2003
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pubmed:articleTitle |
Selective COX-2 inhibition improves endothelial function in coronary artery disease.
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pubmed:affiliation |
Cardiovascular Center, Cardiology and Department of Rheumatology, University Hospital Zürich, Switzerland.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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