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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2003-1-22
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pubmed:abstractText |
As androgens play an essential role in prostate cancer, we sought to develop a real-time PCR to characterize mRNA expression profiles of human members of the Aldo-Keto Reductase (AKR) 1C gene family, as well as of 5 alpha-steroid reductase Type II (SRD5A2) in prostate cancer samples. Functional activity and regulation of AKR1C2, a 3 alpha-hydroxysteroid dehydrogenase (HSD) type III, was also assessed in prostate cancer cell lines.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/20-Hydroxysteroid Dehydrogenases,
http://linkedlifedata.com/resource/pubmed/chemical/3 alpha-beta, 20...,
http://linkedlifedata.com/resource/pubmed/chemical/3-Hydroxysteroid Dehydrogenases,
http://linkedlifedata.com/resource/pubmed/chemical/3-alpha-Hydroxysteroid...,
http://linkedlifedata.com/resource/pubmed/chemical/AKR1C2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Androgens,
http://linkedlifedata.com/resource/pubmed/chemical/Cholestenone 5 alpha-Reductase,
http://linkedlifedata.com/resource/pubmed/chemical/Dihydrotestosterone,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxysteroid Dehydrogenases,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidoreductases,
http://linkedlifedata.com/resource/pubmed/chemical/trans-1,2-dihydrobenzene-1,2-diol...
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0270-4137
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2003 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
275-89
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12539226-20-Hydroxysteroid Dehydrogenases,
pubmed-meshheading:12539226-3-Hydroxysteroid Dehydrogenases,
pubmed-meshheading:12539226-3-alpha-Hydroxysteroid Dehydrogenase (B-Specific),
pubmed-meshheading:12539226-Androgens,
pubmed-meshheading:12539226-Carcinoma, Hepatocellular,
pubmed-meshheading:12539226-Cholestenone 5 alpha-Reductase,
pubmed-meshheading:12539226-Dihydrotestosterone,
pubmed-meshheading:12539226-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:12539226-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:12539226-Humans,
pubmed-meshheading:12539226-Hydroxysteroid Dehydrogenases,
pubmed-meshheading:12539226-Male,
pubmed-meshheading:12539226-Oxidoreductases,
pubmed-meshheading:12539226-Polymerase Chain Reaction,
pubmed-meshheading:12539226-Prostate,
pubmed-meshheading:12539226-Prostatic Neoplasms,
pubmed-meshheading:12539226-Transfection,
pubmed-meshheading:12539226-Tumor Cells, Cultured
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pubmed:year |
2003
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pubmed:articleTitle |
Selective reduction of AKR1C2 in prostate cancer and its role in DHT metabolism.
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pubmed:affiliation |
Division of Gastrointestinal and Liver Disease, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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