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rdf:type |
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lifeskim:mentions |
umls-concept:C0026336,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0040300,
umls-concept:C0205191,
umls-concept:C0205216,
umls-concept:C0205391,
umls-concept:C0268263,
umls-concept:C0597198,
umls-concept:C0871261,
umls-concept:C1274040,
umls-concept:C1417332,
umls-concept:C1513492,
umls-concept:C1704632,
umls-concept:C1705994,
umls-concept:C1706817,
umls-concept:C2584321,
umls-concept:C2911692
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pubmed:issue |
1
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pubmed:dateCreated |
2002-12-31
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pubmed:abstractText |
This study investigated changes in motor skills and tissues of the upper extremity (UE) with regard to injury and inflammatory reactions resulting from performance of a voluntary forelimb repetitive reaching and grasping task in rats. Rats reached for food at a rate of 4 reaches/min, 2 h/day, and 3 days/week for up to 8 weeks during which reach rate, task duration and movement strategies were observed. UE tissues were collected bilaterally at weekly time points of 3-8 weeks and examined for morphological changes. Serum was tested for levels of interleukin-1alpha (IL-1) protein. The macrophage-specific antibody, ED1, was used to identify infiltrating macrophages and the ED2 antibody was used to identify resident macrophages. Rats were unable to maintain baseline reach rate in weeks 5 and 6 of task performance. Alternative patterns of movement emerged. Fraying of tendon fibrils was observed after 6 weeks in the mid-forelimb. After 4 weeks, a general elevation of ED1-IR macrophages were seen in all tissues examined bilaterally including the contralateral, uninvolved forelimb and hindlimbs. Significantly more resident macrophages were seen at 6 and 8 weeks in the reach limb. At 8 weeks, serum levels of IL-1alpha increased significantly above week 0. Our results demonstrate that performance of repetitive tasks elicits motor decrements, signs of injury and a cellular and tissue responses associated with inflammation.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12507595-10450768,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12507595-10759188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12507595-11102904,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12507595-11856068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12507595-1571101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12507595-1656175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12507595-2073355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12507595-2197218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12507595-2783864,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12507595-3543052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12507595-3790459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12507595-6826426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12507595-7108218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12507595-7481277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12507595-7821959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12507595-7961247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12507595-7961275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12507595-8388071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12507595-8434646,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12507595-8622719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12507595-8647349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12507595-8992610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12507595-9062569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12507595-9211609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12507595-9212193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12507595-9283561,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12507595-9339142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12507595-9429905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12507595-9543358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12507595-9543360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12507595-9670224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12507595-9842381
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0736-0266
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
167-76
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12507595-Animals,
pubmed-meshheading:12507595-Behavior, Animal,
pubmed-meshheading:12507595-Cumulative Trauma Disorders,
pubmed-meshheading:12507595-Disease Models, Animal,
pubmed-meshheading:12507595-Female,
pubmed-meshheading:12507595-Hand Strength,
pubmed-meshheading:12507595-Interleukin-1,
pubmed-meshheading:12507595-Macrophages,
pubmed-meshheading:12507595-Motor Skills,
pubmed-meshheading:12507595-Musculoskeletal Diseases,
pubmed-meshheading:12507595-Rats,
pubmed-meshheading:12507595-Rats, Sprague-Dawley,
pubmed-meshheading:12507595-Tendon Injuries,
pubmed-meshheading:12507595-Tendons
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pubmed:year |
2003
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pubmed:articleTitle |
Chronic repetitive reaching and grasping results in decreased motor performance and widespread tissue responses in a rat model of MSD.
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pubmed:affiliation |
Department of Physical Therapy, College of Allied Health Professions, Temple University, 3307 North Broad Street, Philadelphia, PA 19140, USA. mbarbe@temple.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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