Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2002-12-30
pubmed:abstractText
Engrailed is a key transcriptional regulator in the nervous system and in the maintenance of developmental boundaries in Drosophila, and its vertebrate homologs regulate brain and limb development. Here, we show that the functions of both of the Hox cofactors Extradenticle and Homothorax play essential roles in repression by Engrailed. Mutations that remove either of them abrogate the ability of Engrailed to repress its target genes in embryos, both cofactors interact directly with Engrailed, and both stimulate repression by Engrailed in cultured cells. We suggest a model in which Engrailed, Extradenticle and Homothorax function as a complex to repress Engrailed target genes. These studies expand the functional requirements for extradenticle and homothorax beyond the Hox proteins to a larger family of non-Hox homeodomain proteins.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12506004-10082572, http://linkedlifedata.com/resource/pubmed/commentcorrection/12506004-10215621, http://linkedlifedata.com/resource/pubmed/commentcorrection/12506004-10226011, http://linkedlifedata.com/resource/pubmed/commentcorrection/12506004-10373562, http://linkedlifedata.com/resource/pubmed/commentcorrection/12506004-10398683, http://linkedlifedata.com/resource/pubmed/commentcorrection/12506004-10523646, http://linkedlifedata.com/resource/pubmed/commentcorrection/12506004-10529430, http://linkedlifedata.com/resource/pubmed/commentcorrection/12506004-10654609, http://linkedlifedata.com/resource/pubmed/commentcorrection/12506004-10704846, http://linkedlifedata.com/resource/pubmed/commentcorrection/12506004-10823906, http://linkedlifedata.com/resource/pubmed/commentcorrection/12506004-11010815, http://linkedlifedata.com/resource/pubmed/commentcorrection/12506004-11279116, 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pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Insect Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors, http://linkedlifedata.com/resource/pubmed/chemical/Wnt1 Protein, http://linkedlifedata.com/resource/pubmed/chemical/engrail protein, Drosophila, http://linkedlifedata.com/resource/pubmed/chemical/extradenticle protein, Drosophila, http://linkedlifedata.com/resource/pubmed/chemical/homothorax protein, Drosophila, http://linkedlifedata.com/resource/pubmed/chemical/slp1 protein, Drosophila, http://linkedlifedata.com/resource/pubmed/chemical/wg protein, Drosophila
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0950-1991
pubmed:author
pubmed:issnType
Print
pubmed:volume
130
pubmed:owner
NLM
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