Source:http://linkedlifedata.com/resource/pubmed/id/12505266
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2002-12-30
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pubmed:abstractText |
Cryptic translocations in acute promyelocytic leukemia are rare. Usually the gene fusion PML/RARA is located on chromosome 15. Combined cytogenetic, fluorescence in situ hybridization (FISH), and molecular (polymerase chain reaction [PCR]) analysis were employed for the diagnosis and precise localization of the fusion gene. Conventional cytogenetics showed a normal karyotype; PCR showed a typical PML/RARA rearrangement in exon 1. FISH analysis revealed that a submicroscopic part of chromosome 15 had been inserted into 17q. This case adds further information on alternative ways of rearrangement of the PML/RARA genes, possibly correlated with all-trans retinoic acid resistance.
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pubmed:commentsCorrections | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0165-4608
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
138
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
169-73
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12505266-Adult,
pubmed-meshheading:12505266-Chromosomes, Human, Pair 17,
pubmed-meshheading:12505266-Female,
pubmed-meshheading:12505266-Humans,
pubmed-meshheading:12505266-In Situ Hybridization, Fluorescence,
pubmed-meshheading:12505266-Karyotyping,
pubmed-meshheading:12505266-Leukemia, Promyelocytic, Acute,
pubmed-meshheading:12505266-Neoplasm Proteins,
pubmed-meshheading:12505266-Oncogene Proteins, Fusion,
pubmed-meshheading:12505266-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:12505266-Translocation, Genetic
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pubmed:year |
2002
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pubmed:articleTitle |
Cryptic translocation of PML/RARA on 17q. A rare event in acute promyelocytic leukemia.
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pubmed:affiliation |
Hematology Unit, Santa Maria delle Croci Hospital, Viale Randi 5, 48100, Ravenna, Italy.
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pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
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