Linked Life Data

12499841

Source:http://linkedlifedata.com/resource/pubmed/id/12499841

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
18
pubmed:dateCreated
2002-12-24
pubmed:abstractText
R28 retinal progenitor cells offer the potential to replace damaged neurons; however, their ability to differentiate into the appropriate phenotype may depend on whether they express glutamatergic and GABAergic receptors. Whole-cell recordings and immunocytochemistry were used to identify glutamatergic and GABAergic receptors on proliferating R28 cells. R28 cells lacked voltage-gated channels; however, they produced inward currents when non-NMDA, NMDA, GABAa and GABAb receptor agonists were perfused onto the cells. R28 cells were immunoreactive to GluR1, 2 and 3, NMDA and GABAa receptors consistent with electrophysiological results. These results indicate that R28 progenitor cells express glutamatergic and GABAergic receptors capable of influencing their fate and function when grafted into retina or elsewhere in the nervous system.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2421-4
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Retinal precursor cells express functional ionotropic glutamate and GABA receptors.
pubmed:affiliation
Department of Ophthalmology, Physiology and Biophysics, SUNY University at Buffalo, Buffalo, NY 14214, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.